| Disease Specific Interactions between Host Protein and DME (HOSPPI) |
| ICD Disease Classification Healthy |
| ICD-11: Healthy |
Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
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| Transcription-factor regulation |
| Proto-oncogene c-Fos (FOS) |
Health |
Activation |
| Uniprot ID |
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| Interaction Name |
FOS-SRR interaction |
[1] |
| Studied Cell Lines |
HAPI, BV-2 and N9 cell lines |
| Ensembl ID |
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| Description |
Proto-oncogene c-Fos (FOS) is reported to activate the transcription of SRR gene, which leads to an increased expression of the drug-metabolizing enzyme Serine racemase. As a result, the interaction between FOS and SRR can activate the drug-metabolizing process of Serine racemase. |
| ICD Disease Classification 02 Neoplasms |
| ICD-11: 2A11 Brain neuroblastoma |
Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
|
| Histone modification |
| Histone deacetylases (HDACs) |
Neuroblastoma |
Repression |
| Uniprot ID |
|
| Interaction Name |
HDACs-SRR interaction |
[2] |
| Studied Cell Lines |
Neuro-2a cell line |
| Description |
Histone deacetylases (HDACs) are reported to deacetylate the SRR gene and thereby repress the transcriptional activity of the drug-metabolizing enzyme Serine racemase. As a result, the interaction between HDACs and SRR can inhibit the drug-metabolizing process of Serine racemase. |
| ICD-11: 2B51 Osteosarcoma |
Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
|
| Non-coding RNA regulation |
| hsa-miR-193a-5p |
Osteosarcoma |
Suppression |
| miRBase ID |
|
| Interaction Name |
hsa-miR-193a-5p--SRR regulation |
[3] |
| Studied Cell Lines |
MG63 cell line |
| Description |
hsa-miR-193a-5p is reported to suppress SRR mRNA translation by binding to the 3' untranslated region (3'UTR) of SRR mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Serine racemase. |
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