Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0589)
DME Name	Prostaglandin E synthase 2 (PTGES2), Homo sapiens	DME Info
UniProt ID	PGES2_HUMAN
EC Number	EC: 5.3.99.3 (Click to Show/Hide the Complete EC Tree) Isomerase Intramolecular oxidoreductase Intramolecular oxidoreductase EC: 5.3.99.3
Lineage	Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens
Interactome

Disease Specific Interactions between Host Protein and DME (HOSPPI)
ICD Disease Classification Healthy
ICD-11: Healthy		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
Non-coding RNA regulation
hsa-miR-146a-5p		Health		Suppression
miRBase ID	MIMAT0000449
Interaction Name	hsa-miR-146a-5p--PTGES2 regulation				[1]
Studied Cell Lines	Bone marrow-derived mesenchymal stem cells
Description	hsa-miR-146a-5p is reported to suppress PTGES2 mRNA translation by binding to the 3' untranslated region (3'UTR) of PTGES2 mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Prostaglandin E synthase 2.
ICD Disease Classification 02 Neoplasms
ICD-11: 2A00 Brain cancer		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Cerebellar liponeurocytoma		Significant hypomethylation
Interaction Name	DNMT-PTGES2 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 4.92E-05; delta-beta: -4.59E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the PTGES2 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Prostaglandin E synthase 2. As a result, the interaction between DNMT and PTGES2 can significantly affect the drug-metabolizing process of Prostaglandin E synthase 2.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual

References
1	MicroRNA-146a negatively regulates the immunoregulatory activity of bone marrow stem cells by targeting prostaglandin E2 synthase-2. J Immunol. 2013 May 15;190(10):5102-9.

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