Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0590)
DME Name Spermine oxidase (SMOX), Homo sapiens DME Info
UniProt ID
SMOX_HUMAN
EC Number    EC: 1.5.3.16     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-NH donor oxidoreductase
Oxygen acceptor oxidoreductase
EC: 1.5.3.16
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      ICD Disease Classification 02 Neoplasms
               ICD-11: 2A00 Brain cancer Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     DNA methylation
                            DNA methyltransferase (DNMT) Brain neuroblastoma Moderate hypomethylation
Interaction Name DNMT-SMOX interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue Moderate hypomethylation
p-value: 2.50E-12; delta-beta: -2.73E-01
Description DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the SMOX gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Spermine oxidase. As a result, the interaction between DNMT and SMOX can moderatly affect the drug-metabolizing process of Spermine oxidase.
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples
Download DME methylation data of patients in the disease section of the tissue
Download DME methylation data in the tissue of healthy individual
               ICD-11: 2B71 Gastric cancer Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     Non-coding RNA regulation
                            hsa-miR-124-3p Gastric cancer Suppression
miRBase ID
MIMAT0000422
Interaction Name hsa-miR-124-3p--SMOX regulation [1]
Studied Cell Lines AGS cell line
Description hsa-miR-124-3p is reported to suppress SMOX mRNA translation by binding to the 3' untranslated region (3'UTR) of SMOX mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Spermine oxidase.
References
1 Epigenetic silencing of miR-124 prevents spermine oxidase regulation: implications for Helicobacter pylori-induced gastric cancer. Oncogene. 2016 Oct 20;35(42):5480-5488.

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