General Information of Drug-Metabolizing Enzyme (DME ID: DME0591)
DME Name Sterol Delta(7)-reductase (DHCR7), Homo sapiens DME Info
UniProt ID
DHCR7_HUMAN
EC Number    EC: 1.3.1.21     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-CH donor oxidoreductase
NAD/NADP acceptor oxidoreductase
EC: 1.3.1.21
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      ICD Disease Classification 02 Neoplasms
               ICD-11: 2A00 Brain cancer Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     DNA methylation
                            DNA methyltransferase (DNMT) Peripheral neuroectodermal tumour Significant hypomethylation
Interaction Name DNMT-DHCR7 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue Significant hypomethylation
p-value: 2.55E-06; delta-beta: -3.00E-01
Description DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the DHCR7 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Sterol Delta(7)-reductase. As a result, the interaction between DNMT and DHCR7 can significantly affect the drug-metabolizing process of Sterol Delta(7)-reductase.
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level Click to View the Clearer Original Diagram

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.