Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0593)
DME Name	Carboxypeptidase A4 (CPA4), Homo sapiens	DME Info
UniProt ID	CBPA4_HUMAN
EC Number	EC: 3.4.17.1 (Click to Show/Hide the Complete EC Tree) Hydrolases Peptidase Metallocarboxypeptidase EC: 3.4.17.1
Lineage	Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens
Interactome

Disease Specific Interactions between Host Protein and DME (HOSPPI)
ICD Disease Classification 02 Neoplasms
ICD-11: 2A00 Brain cancer		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Cerebellar liponeurocytoma		Significant hypomethylation
Interaction Name	DNMT-CPA4 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 4.11E-05; delta-beta: -5.17E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the CPA4 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Carboxypeptidase A4. As a result, the interaction between DNMT and CPA4 can significantly affect the drug-metabolizing process of Carboxypeptidase A4.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD-11: 2C12 Liver cancer		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Liver cancer		Significant hypomethylation
Interaction Name	DNMT-CPA4 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 6.63E-13; delta-beta: -3.35E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the CPA4 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Carboxypeptidase A4. As a result, the interaction between DNMT and CPA4 can significantly affect the drug-metabolizing process of Carboxypeptidase A4.
The Methylation Level of Disease Section Compare with the Adjacent Tissue	Significant hypomethylation p-value: 4.05E-14; delta-beta: -3.39E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the CPA4 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Carboxypeptidase A4. As a result, the interaction between DNMT and CPA4 can significantly affect the drug-metabolizing process of Carboxypeptidase A4.
The Methylation Level of Disease Section Compare with the Other Disease Section	Moderate hypomethylation p-value: 4.88E-04; delta-beta: -2.98E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the CPA4 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Carboxypeptidase A4. As a result, the interaction between DNMT and CPA4 can moderatly affect the drug-metabolizing process of Carboxypeptidase A4.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue adjacent to the diseased tissue of patients DME methylation in the normal tissue of healthy individuals DME methylation in tissue other than the diseased tissue of patients
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data of patients in the normal section of the tissue adjacent to the disease section Download DME methylation data in the tissue of healthy individual Download DME methylation data in the tissue of the other disease section
ICD-11: 2C82 Prostate cancer		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
Histone modification
Histone deacetylases (HDACs)		Prostate cancer		Repression
Uniprot ID	HDAC1_HUMAN
Interaction Name	HDACs-CPA4 interaction				[1]
Studied Cell Lines	prostate cancer cells
Description	Histone deacetylases (HDACs) are reported to deacetylate the CPA4 gene and thereby repress the transcriptional activity of the drug-metabolizing enzyme Carboxypeptidase A4. As a result, the interaction between HDACs and CPA4 can inhibit the drug-metabolizing process of Carboxypeptidase A4.

References
1	Structure of human carboxypeptidase A4 with its endogenous protein inhibitor, latexin. Proc Natl Acad Sci U S A. 2005 Mar 15;102(11):3978-83.

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