Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME0613) | |||||
|---|---|---|---|---|---|
| DME Name | Glutathione S-transferase mu-4 (GSTM4), Homo sapiens | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 2.5.1.18 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| ICD Disease Classification 02 Neoplasms | |||||
| ICD-11: 2A00 Brain cancer | Click to Show/Hide the Full List of HOSPPI: 2 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Brain neuroblastoma | Significant hypomethylation | |||
| Interaction Name | DNMT-GSTM4 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 2.02E-23; delta-beta: -3.37E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the GSTM4 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Glutathione S-transferase mu-4. As a result, the interaction between DNMT and GSTM4 can significantly affect the drug-metabolizing process of Glutathione S-transferase mu-4. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Cerebellar liponeurocytoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-GSTM4 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 8.66E-03; delta-beta: -2.60E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the GSTM4 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Glutathione S-transferase mu-4. As a result, the interaction between DNMT and GSTM4 can moderatly affect the drug-metabolizing process of Glutathione S-transferase mu-4. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
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