General Information of Drug-Metabolizing Enzyme (DME ID: DME0616)
DME Name Docosahexaenoic acid omega-hydroxylase (CYP4F11), Homo sapiens DME Info
UniProt ID
CP4FB_HUMAN
EC Number    EC: 1.14.14.1     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen paired donor oxidoreductase
Flavin/flavoprotein donor oxidoreductase
EC: 1.14.14.1
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      ICD Disease Classification 02 Neoplasms
               ICD-11: 2A00 Brain cancer Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     DNA methylation
                            DNA methyltransferase (DNMT) Multilayered rosettes embryonal tumour Significant hypomethylation
Interaction Name DNMT-CYP4F11 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue Significant hypomethylation
p-value: 4.75E-21; delta-beta: -4.64E-01
Description DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the CYP4F11 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Docosahexaenoic acid omega-hydroxylase. As a result, the interaction between DNMT and CYP4F11 can significantly affect the drug-metabolizing process of Docosahexaenoic acid omega-hydroxylase.
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level Click to View the Clearer Original Diagram

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