Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME0623) | |||||
|---|---|---|---|---|---|
| DME Name | Epoxide hydrolase 1 (EPHX1), Homo sapiens | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 3.3.2.9 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| ICD Disease Classification 02 Neoplasms | |||||
| ICD-11: 2B30 Lymphoma | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Lymphoma | Significant hypomethylation | |||
| Interaction Name | DNMT-EPHX1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 1.21E-10; delta-beta: -3.86E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the EPHX1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Epoxide hydrolase 1. As a result, the interaction between DNMT and EPHX1 can significantly affect the drug-metabolizing process of Epoxide hydrolase 1. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2B71 Gastric cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Gastric cancer | Moderate hypomethylation | |||
| Interaction Name | DNMT-EPHX1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Adjacent Tissue | Moderate hypomethylation p-value: 6.54E-03; delta-beta: -2.81E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the EPHX1 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Epoxide hydrolase 1. As a result, the interaction between DNMT and EPHX1 can moderatly affect the drug-metabolizing process of Epoxide hydrolase 1. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue adjacent to the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2D50 Brain cancer metastasis | Click to Show/Hide the Full List of HOSPPI: 2 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Esthesioneuroblastoma | Significant hypomethylation | |||
| Interaction Name | DNMT-EPHX1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 2.23E-12; delta-beta: -4.65E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the EPHX1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Epoxide hydrolase 1. As a result, the interaction between DNMT and EPHX1 can significantly affect the drug-metabolizing process of Epoxide hydrolase 1. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Posterior fossa ependymoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-EPHX1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 3.50E-53; delta-beta: -2.88E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the EPHX1 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Epoxide hydrolase 1. As a result, the interaction between DNMT and EPHX1 can moderatly affect the drug-metabolizing process of Epoxide hydrolase 1. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.