| Disease Specific Interactions between Host Protein and DME (HOSPPI) |
| ICD Disease Classification Healthy |
| ICD-11: Healthy |
Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
|
| Histone modification |
| Histone deacetylase 2 (HDAC2) |
Health |
Repression |
| Uniprot ID |
|
| Interaction Name |
HDAC2-CYP7A1 interaction |
[1] |
| Studied Cell Lines |
Mouse Model |
| Description |
Histone deacetylase 2 (HDAC2) s-nitrosylation is reported to deacetylate the CYP7A1 gene and thereby represses the transcriptional activity of the drug-metabolizing enzyme Cytochrome P450 7A1. As a result, the interaction between HDAC2 and CYP7A1 can inhibit the drug-metabolizing process of Cytochrome P450 7A1. |
| ICD Disease Classification 02 Neoplasms |
| ICD-11: 2C12 Liver cancer |
Click to Show/Hide the Full List of HOSPPI: 2 HOSPPI
|
| Non-coding RNA regulation |
| hsa-miR-122-5p |
Liver cancer |
Suppression |
| miRBase ID |
|
| Interaction Name |
hsa-miR-122-5p--CYP7A1 regulation |
[2] |
| Studied Cell Lines |
HepG2 cell line |
| Description |
hsa-miR-122-5p is reported to suppress CYP7A1 mRNA translation by binding to the 3' untranslated region (3'UTR) of CYP7A1 mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Cytochrome P450 7A1. |
| hsa-miR-422a |
Liver cancer |
Suppression |
| miRBase ID |
|
| Interaction Name |
hsa-miR-422a--CYP7A1 regulation |
[2] |
| Studied Cell Lines |
HepG2 cell line |
| Description |
hsa-miR-422a is reported to suppress CYP7A1 mRNA translation by binding to the 3' untranslated region (3'UTR) of CYP7A1 mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Cytochrome P450 7A1. |
| ICD Disease Classification 05 Endocrine/nutritional/metabolic diseases |
| ICD-11: 5A11 Type II diabetic |
Click to Show/Hide the Full List of HOSPPI: 4 HOSPPI
|
| Histone modification |
| Histone deacetylase 3 (HDAC3) |
Type II diabetic |
Repression |
| Uniprot ID |
|
| Interaction Name |
HDAC3-CYP7A1 interaction |
[3] |
| Studied Cell Lines |
Humanized CYP7A1-transgenic mice |
| Description |
Histone deacetylase 3 (HDAC3) is reported to deacetylate the CYP7A1 gene and thereby represses the transcriptional activity of the drug-metabolizing enzyme Cytochrome P450 7A1. As a result, the interaction between HDAC3 and CYP7A1 can inhibit the drug-metabolizing process of Cytochrome P450 7A1. |
| Histone deacetylase 4 (HDAC4) |
Type II diabetic |
Repression |
| Uniprot ID |
|
| Interaction Name |
HDAC4-CYP7A1 interaction |
[3] |
| Studied Cell Lines |
Humanized CYP7A1-transgenic mice |
| Description |
Histone deacetylase 4 (HDAC4) is reported to deacetylate the CYP7A1 gene and thereby represses the transcriptional activity of the drug-metabolizing enzyme Cytochrome P450 7A1. As a result, the interaction between HDAC4 and CYP7A1 can inhibit the drug-metabolizing process of Cytochrome P450 7A1. |
| Histone methyltransferases (HMTs) |
Type II diabetic |
Repression |
| Uniprot ID |
|
| Interaction Name |
HMTs-CYP7A1 interaction |
[3] |
| Studied Cell Lines |
Humanized CYP7A1-transgenic mice |
| Description |
The Histone 3 lysine 9 dimethylation of CYP7A1 gene is reported to repress the transcriptional activity of the drug-metabolizing enzyme Cytochrome P450 7A1. As a result, the interaction between Histone methyltransferases (HMTs) and CYP7A1 can inhibit the drug-metabolizing process of Cytochrome P450 7A1. |
| Histone methyltransferases (HMTs) |
Type II diabetic |
Repression |
| Uniprot ID |
|
| Interaction Name |
HMTs-CYP7A1 interaction |
[3] |
| Studied Cell Lines |
Humanized CYP7A1-transgenic mice |
| Description |
The Histone 3 lysine 9 trimethylation of CYP7A1 gene is reported to repress the transcriptional activity of the drug-metabolizing enzyme Cytochrome P450 7A1. As a result, the interaction between Histone methyltransferases (HMTs) and CYP7A1 can inhibit the drug-metabolizing process of Cytochrome P450 7A1. |
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