General Information of Drug-Metabolizing Enzyme (DME ID: DME0633)
DME Name Glutathione S-transferase zeta-1 (GSTZ1), Homo sapiens DME Info
UniProt ID
MAAI_HUMAN
EC Number    EC: 2.5.1.18     (Click to Show/Hide the Complete EC Tree)
Transferase
Alkyl/aryl transferase
Alkyl/aryl transferase
EC: 2.5.1.18
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      ICD Disease Classification 02 Neoplasms
               ICD-11: 2A00 Brain cancer Click to Show/Hide the Full List of HOSPPI:        3 HOSPPI
                     DNA methylation
                            DNA methyltransferase (DNMT) Cerebellar liponeurocytoma Significant hypomethylation
Interaction Name DNMT-GSTZ1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue Significant hypomethylation
p-value: 9.85E-05; delta-beta: -4.52E-01
Description DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the GSTZ1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Glutathione S-transferase zeta-1. As a result, the interaction between DNMT and GSTZ1 can significantly affect the drug-metabolizing process of Glutathione S-transferase zeta-1.
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level Click to View the Clearer Original Diagram
                            DNA methyltransferase (DNMT) Brain neuroblastoma Significant hypomethylation
Interaction Name DNMT-GSTZ1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue Significant hypomethylation
p-value: 5.75E-16; delta-beta: -3.03E-01
Description DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the GSTZ1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Glutathione S-transferase zeta-1. As a result, the interaction between DNMT and GSTZ1 can significantly affect the drug-metabolizing process of Glutathione S-transferase zeta-1.
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level Click to View the Clearer Original Diagram
                            DNA methyltransferase (DNMT) Multilayered rosettes embryonal tumour Moderate hypomethylation
Interaction Name DNMT-GSTZ1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue Moderate hypomethylation
p-value: 2.58E-16; delta-beta: -2.64E-01
Description DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the GSTZ1 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Glutathione S-transferase zeta-1. As a result, the interaction between DNMT and GSTZ1 can moderatly affect the drug-metabolizing process of Glutathione S-transferase zeta-1.
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level Click to View the Clearer Original Diagram

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