| General Information of Drug-Metabolizing Enzyme (DME ID: DME0640) |
| DME Name |
UDP-glucuronosyltransferase 2B11 (UGT2B11), Homo sapiens
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DME Info
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| UniProt ID |
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| EC Number |
EC: 2.4.1.17 (Click to Show/Hide the Complete EC Tree)
Transferase
Glycosyltransferases
Hexosyltransferase
EC: 2.4.1.17
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| Lineage |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Interactome |
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| Disease Specific Interactions between Host Protein and DME (HOSPPI) |
| ICD Disease Classification 02 Neoplasms |
| ICD-11: 2C82 Prostate cancer |
Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
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| Histone modification |
| Histone deacetylases (HDACs) |
Prostate cancer |
Repression |
| Uniprot ID |
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| Interaction Name |
HDACs-UGT2B11 interaction |
[1] |
| Studied Cell Lines |
LNCaP cell line |
| Description |
Histone deacetylases (HDACs) are reported to deacetylate the UGT2B11 gene and thereby repress the transcriptional activity of the drug-metabolizing enzyme UDP-glucuronosyltransferase 2B11. As a result, the interaction between HDACs and UGT2B11 can inhibit the drug-metabolizing process of UDP-glucuronosyltransferase 2B11. |
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| References |
| 1 |
Valproic acid induces neuroendocrine differentiation and UGT2B7 up-regulation in human prostate carcinoma cell line. Drug Metab Dispos. 2007 Jun;35(6):968-72.
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