Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1004)
DME Name Beta-lactamase (blaB), Enterobacter cloacae DME Info
UniProt ID
A0A1S7IV31_ENTAS
EC Number    EC: 3.5.2.6     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Carbon-nitrogen hydrolase
Cyclic amide hydrolase
EC: 3.5.2.6
Lineage    Species: Enterobacter cloacae     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Enterobacteriaceae
Genus: Enterobacter
Species: Enterobacter cloacae
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      Drug co-metabolism
               Cometabolized drug: Doripenem Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                            Dehydropeptidase-I (DPEP1) Click to Show/Hide the Cometabolization Info
DME ID DME0117 DME Info
Uniprot ID
DPEP1_HUMAN
Interaction Name DPEP1-blaB interaction [1], [2]
Description The interaction, between human Dehydropeptidase-I and Beta-lactamase from Enterobacter cloacae which collectively metabolize the drug Doripenem, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
References
1 FRI-4 carbapenemase-producing Enterobacter cloacae complex isolated in Tokyo, Japan. J Antimicrob Chemother. 2018 Nov 1;73(11):2969-2972.
2 Disposition, metabolism, and excretion of [14C]doripenem after a single 500-milligram intravenous infusion in healthy men. Antimicrob Agents Chemother. 2008 Oct;52(10):3478-83.

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