Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME1028) | |||||
|---|---|---|---|---|---|
| DME Name | Chloramphenicolase (chlR), Escherichia coli | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 2.3.1.28 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Escherichia coli (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| Drug co-metabolism | |||||
| Cometabolized drug: Chloramphenicol | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| Mephenytoin 4-hydroxylase (CYP2C19) | Click to Show/Hide the Cometabolization Info | ||||
| DME ID | DME0021 DME Info | ||||
| Uniprot ID | |||||
| Interaction Name | CYP2C19-chlR interaction | [1], [2] | |||
| Description | The interaction, between human Mephenytoin 4-hydroxylase and Chloramphenicolase from Escherichia coli which collectively metabolize the drug Chloramphenicol, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism. | ||||
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