Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1029)
DME Name Glycerol-3-phosphate dehydrogenase (gpsA), Erysipelothrix rhusiopathiae DME Info
UniProt ID
A0A411LCN0_ERYRH
EC Number    EC: 1.1.1.94     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-OH donor oxidoreductase
NAD/NADP oxidoreductase
EC: 1.1.1.94
Lineage    Species: Erysipelothrix rhusiopathiae     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Erysipelotrichia
Order: Erysipelotrichales
Family: Erysipelotrichaceae
Genus: Erysipelothrix
Species: Erysipelothrix rhusiopathiae
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      Drug co-metabolism
               Cometabolized drug: Chloramphenicol Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                            Mephenytoin 4-hydroxylase (CYP2C19) Click to Show/Hide the Cometabolization Info
DME ID DME0021 DME Info
Uniprot ID
CP2CJ_HUMAN
Interaction Name CYP2C19-gpsA interaction [1], [2], [3]
Description The interaction, between human Mephenytoin 4-hydroxylase and Glycerol-3-phosphate dehydrogenase from Erysipelothrix rhusiopathiae which collectively metabolize the drug Chloramphenicol, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
References
1 Porcine beta-defensin 2 displays broad antimicrobial activity against pathogenic intestinal bacteria. Mol Immunol. 2008 Jan;45(2):386-94.
2 Dehydrogenase activity of chlornitromycin-resistant variants of Erysipelothrix rhusiopathiae. Izv Mikrobiol Inst (Sofiia). 1969;20:257-62.
3 Chloramphenicol is a potent inhibitor of cytochrome P450 isoforms CYP2C19 and CYP3A4 in human liver microsomes. Antimicrob Agents Chemother. 2003 Nov;47(11):3464-9.

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