| General Information of Drug-Metabolizing Enzyme (DME ID: DME1030) |
| DME Name |
Chloramphenicolase (chlR), Bacillus pumilus
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DME Info
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| UniProt ID |
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| EC Number |
EC: 2.3.1.28 (Click to Show/Hide the Complete EC Tree)
Transferase
Acyltransferase
Acyltransferase
EC: 2.3.1.28
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| Lineage |
Species: Bacillus pumilus (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Bacillales
Family: Bacillaceae
Genus: Bacillus
Species: Bacillus pumilus
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| Interactome |
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| Disease Specific Interactions between Host Protein and DME (HOSPPI) |
| Drug co-metabolism |
| Cometabolized drug: Chloramphenicol |
Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
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| Mephenytoin 4-hydroxylase (CYP2C19) |
Click to Show/Hide the Cometabolization Info |
| DME ID |
DME0021
DME Info
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| Uniprot ID |
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| Interaction Name |
CYP2C19-chlR interaction |
[1], [2] |
| Description |
The interaction, between human Mephenytoin 4-hydroxylase and Chloramphenicolase from Bacillus pumilus which collectively metabolize the drug Chloramphenicol, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism. |
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| References |
| 1 |
The bacterial degradation of chloramphenico. Lancet. 1967 Jun 10;1(7502):1259-60.
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| 2 |
Chloramphenicol is a potent inhibitor of cytochrome P450 isoforms CYP2C19 and CYP3A4 in human liver microsomes. Antimicrob Agents Chemother. 2003 Nov;47(11):3464-9.
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