| General Information of Drug-Metabolizing Enzyme (DME ID: DME1043) |
| DME Name |
Beta-glucosidase (bglA), Malassezia furfur
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DME Info
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| UniProt ID |
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| EC Number |
EC: 3.2.1.21 (Click to Show/Hide the Complete EC Tree)
Hydrolases
Glycosylase
O/S-glycosyl compound glycosidase
EC: 3.2.1.21
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| Lineage |
Species: Malassezia furfur (Click to Show/Hide the Complete Species Lineage)
Kingdom: Fungi
Phylum: Basidiomycota
Class: Malasseziomycetes
Order: Malasseziales
Family: Malasseziaceae
Genus: Malassezia
Species: Malassezia furfur
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| Interactome |
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| Disease Specific Interactions between Host Protein and DME (HOSPPI) |
| Drug co-metabolism |
| Cometabolized drug: Esculin |
Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
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| L-glutamine amidohydrolase (GLS) |
Click to Show/Hide the Cometabolization Info |
| DME ID |
DME0126
DME Info
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| Uniprot ID |
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| Interaction Name |
GLS-bglA interaction |
[1], [2] |
| Description |
The interaction, between human L-glutamine amidohydrolase and Beta-glucosidase from Malassezia furfur which collectively metabolize the drug Esculin, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism. |
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| References |
| 1 |
A prodrug approach to the use of coumarins as potential therapeutics for superficial mycoses. PLoS One. 2013 Nov 18;8(11):e80760.
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| 2 |
KEGG: new perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res. 2017 Jan 4;45(D1):D353-D361. (cpd:C09264)
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