General Information of Drug-Metabolizing Enzyme (DME ID: DME1044)
DME Name Beta-glucosidase (bglA), Malassezia sympodialis DME Info
UniProt ID
A0A249DCH3_LACRH
EC Number    EC: 3.2.1.21     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Glycosylase
O/S-glycosyl compound glycosidase
EC: 3.2.1.21
Lineage    Species: Malassezia sympodialis     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Fungi
Phylum: Basidiomycota
Class: Malasseziomycetes
Order: Malasseziales
Family: Malasseziaceae
Genus: Malassezia
Species: Malassezia sympodialis
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      Drug co-metabolism
               Cometabolized drug: Esculin Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                            L-glutamine amidohydrolase (GLS) Click to Show/Hide the Cometabolization Info
DME ID DME0126 DME Info
Uniprot ID
GLSK_HUMAN
Interaction Name GLS-bglA interaction [1], [2]
Description The interaction, between human L-glutamine amidohydrolase and Beta-glucosidase from Malassezia sympodialis which collectively metabolize the drug Esculin, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
References
1 Physiological and molecular characterization of atypical isolates of Malassezia furfur. J Clin Microbiol. 2009 Jan;47(1):48-53.
2 KEGG: new perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res. 2017 Jan 4;45(D1):D353-D361. (cpd:C09264)

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