Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1045)
DME Name	Beta-glucosidase (bglA), Trichophyton interdigitale	DME Info
UniProt ID	A0A059IXB8_TRIIM
EC Number	EC: 3.2.1.21 (Click to Show/Hide the Complete EC Tree) Hydrolases Glycosylase O/S-glycosyl compound glycosidase EC: 3.2.1.21
Lineage	Species: Trichophyton interdigitale (Click to Show/Hide the Complete Species Lineage) Kingdom: Fungi Phylum: Ascomycota Class: Eurotiomycetes Order: Onygenales Family: Arthrodermataceae Genus: Trichophyton Species: Trichophyton interdigitale Subspecies: Trichophyton interdigitale NCPF 0335
Interactome

Disease Specific Interactions between Host Protein and DME (HOSPPI)
Drug co-metabolism
Cometabolized drug: Esculin		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
L-glutamine amidohydrolase (GLS)		Click to Show/Hide the Cometabolization Info
DME ID	DME0126 DME Info
Uniprot ID	GLSK_HUMAN
Interaction Name	GLS-bglA interaction		[1], [2]
Description	The interaction, between human L-glutamine amidohydrolase and Beta-glucosidase from Trichophyton interdigitale which collectively metabolize the drug Esculin, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.

References
1	A prodrug approach to the use of coumarins as potential therapeutics for superficial mycoses. PLoS One. 2013 Nov 18;8(11):e80760.
2	KEGG: new perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res. 2017 Jan 4;45(D1):D353-D361. (cpd:C09264)

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