Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1047)
DME Name Beta-glucosidase (bglA), Trichophyton rubrum DME Info
UniProt ID
F2SBM1_TRIRC
EC Number    EC: 3.2.1.21     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Glycosylase
O/S-glycosyl compound glycosidase
EC: 3.2.1.21
Lineage    Species: Trichophyton rubrum     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Fungi
Phylum: Ascomycota
Class: Eurotiomycetes
Order: Onygenales
Family: Arthrodermataceae
Genus: Trichophyton
Species: Trichophyton rubrum
Subspecies: Trichophyton rubrum NCPF 0118
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      Drug co-metabolism
               Cometabolized drug: Esculin Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                            L-glutamine amidohydrolase (GLS) Click to Show/Hide the Cometabolization Info
DME ID DME0126 DME Info
Uniprot ID
GLSK_HUMAN
Interaction Name GLS-bglA interaction [1], [2], [3]
Description The interaction, between human L-glutamine amidohydrolase and Beta-glucosidase from Trichophyton rubrum which collectively metabolize the drug Esculin, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
References
1 A prodrug approach to the use of coumarins as potential therapeutics for superficial mycoses. PLoS One. 2013 Nov 18;8(11):e80760.
2 Isolation of transcripts overexpressed in the human pathogen Trichophyton rubrum grown in lipid as carbon source. Can J Microbiol. 2011 Apr;57(4):333-8.
3 KEGG: new perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res. 2017 Jan 4;45(D1):D353-D361. (cpd:C09264)

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