Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1049)
DME Name Dihydrofolate reductase (folA), Escherichia coli DME Info
UniProt ID
DYR_ECOLI
EC Number    EC: 1.5.1.3     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-NH donor oxidoreductase
NAD/NADP acceptor oxidoreductase
EC: 1.5.1.3
Lineage    Species: Escherichia coli     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Enterobacteriaceae
Genus: Escherichia
Species: Escherichia coli
Subspecies: Escherichia coli K-12
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      Drug co-metabolism
               Cometabolized drug: Folic acid Click to Show/Hide the Full List of HOSPPI:        7 HOSPPI
                            Cytochrome P450 2E1 (CYP2E1) Click to Show/Hide the Cometabolization Info
DME ID DME0013 DME Info
Uniprot ID
CP2E1_HUMAN
Interaction Name CYP2E1-folA interaction [1], [2], [3]
Description The interaction, between human Cytochrome P450 2E1 and Dihydrofolate reductase from Escherichia coli which collectively metabolize the drug Folic acid, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Dihydrofolate reductase (DHFR) Click to Show/Hide the Cometabolization Info
DME ID DME0141 DME Info
Uniprot ID
DYR_HUMAN
Interaction Name DHFR-folA interaction [1], [2], [4]
Description The interaction, between human Dihydrofolate reductase and Dihydrofolate reductase from Escherichia coli which collectively metabolize the drug Folic acid, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Gamma-Glu-X carboxypeptidase (GGH) Click to Show/Hide the Cometabolization Info
DME ID DME0142 DME Info
Uniprot ID
GGH_HUMAN
Interaction Name GGH-folA interaction [1], [2], [5]
Description The interaction, between human Gamma-Glu-X carboxypeptidase and Dihydrofolate reductase from Escherichia coli which collectively metabolize the drug Folic acid, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Methionine synthase reductase (MTRR) Click to Show/Hide the Cometabolization Info
DME ID DME0431 DME Info
Uniprot ID
MTRR_HUMAN
Interaction Name MTRR-folA interaction [1], [2], [6]
Description The interaction, between human Methionine synthase reductase and Dihydrofolate reductase from Escherichia coli which collectively metabolize the drug Folic acid, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Methylenetetrahydrofolate reductase (MTHFR) Click to Show/Hide the Cometabolization Info
DME ID DME0083 DME Info
Uniprot ID
MTHR_HUMAN
Interaction Name MTHFR-folA interaction [1], [2], [7]
Description The interaction, between human Methylenetetrahydrofolate reductase and Dihydrofolate reductase from Escherichia coli which collectively metabolize the drug Folic acid, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            RNA cytidine acetyltransferase (hALP) Click to Show/Hide the Cometabolization Info
DME ID DME0007 DME Info
Uniprot ID
NAT10_HUMAN
Interaction Name hALP-folA interaction [1], [2], [8]
Description The interaction, between human RNA cytidine acetyltransferase and Dihydrofolate reductase from Escherichia coli which collectively metabolize the drug Folic acid, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Vitamin B12 methionine synthase (MTR) Click to Show/Hide the Cometabolization Info
DME ID DME0153 DME Info
Uniprot ID
METH_HUMAN
Interaction Name MTR-folA interaction [1], [2], [9]
Description The interaction, between human Vitamin B12 methionine synthase and Dihydrofolate reductase from Escherichia coli which collectively metabolize the drug Folic acid, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
References
1 Measurement of the uptake of radioactive para-aminobenzoic acid monitors folate biosynthesis in Escherichia coli K-12. Anal Biochem. 1994 Feb 1;216(2):427-30.
2 The influence of CsgD on the expression of genes of folate metabolism and hmp in Escherichia coli K-12. Arch Microbiol. 2013 Aug;195(8):559-69.
3 Chronic ethanol feeding and folate deficiency activate hepatic endoplasmic reticulum stress pathway in micropigs. Am J Physiol Gastrointest Liver Physiol. 2005 Jul;289(1):G54-63.
4 The dihydrofolate reductase 19 bp polymorphism is not associated with biomarkers of folate status in healthy young adults, irrespective of folic acid intake. J Nutr. 2015 Oct;145(10):2207-11.
5 Optimization of the trienzyme extraction for the microbiological assay of folate in vegetables. J Agric Food Chem. 2007 May 16;55(10):3884-8.
6 Polymorphisms in genes involved in folate metabolism as maternal risk factors for Down syndrome in China. J Zhejiang Univ Sci B. 2008 Feb;9(2):93-9.
7 Genetic variation: impact on folate (and choline) bioefficacy. Int J Vitam Nutr Res. 2010 Oct;80(4-5):319-29.
8 Arylamine N-acetyltransferase in human red blood cells. Biochem Pharmacol. 1992 Sep 25;44(6):1099-104.
9 Metabolic derangement of methionine and folate metabolism in mice deficient in methionine synthase reductase. Mol Genet Metab. 2007 May;91(1):85-97.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.