Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1051)
DME Name Dihydrofolate reductase (folA), Chlamydia muridarum DME Info
UniProt ID
Q9PJC7_CHLMU
EC Number    EC: 1.5.1.3     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-NH donor oxidoreductase
NAD/NADP acceptor oxidoreductase
EC: 1.5.1.3
Lineage    Species: Chlamydia muridarum     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Chlamydiae
Class: Chlamydiia
Order: Chlamydiales
Family: Chlamydiaceae
Genus: Chlamydia
Species: Chlamydia muridarum
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      Drug co-metabolism
               Cometabolized drug: Folic acid Click to Show/Hide the Full List of HOSPPI:        7 HOSPPI
                            Cytochrome P450 2E1 (CYP2E1) Click to Show/Hide the Cometabolization Info
DME ID DME0013 DME Info
Uniprot ID
CP2E1_HUMAN
Interaction Name CYP2E1-folA interaction [1], [2], [3]
Description The interaction, between human Cytochrome P450 2E1 and Dihydrofolate reductase from Chlamydia muridarum which collectively metabolize the drug Folic acid, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Dihydrofolate reductase (DHFR) Click to Show/Hide the Cometabolization Info
DME ID DME0141 DME Info
Uniprot ID
DYR_HUMAN
Interaction Name DHFR-folA interaction [1], [2], [4]
Description The interaction, between human Dihydrofolate reductase and Dihydrofolate reductase from Chlamydia muridarum which collectively metabolize the drug Folic acid, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Gamma-Glu-X carboxypeptidase (GGH) Click to Show/Hide the Cometabolization Info
DME ID DME0142 DME Info
Uniprot ID
GGH_HUMAN
Interaction Name GGH-folA interaction [1], [2], [5]
Description The interaction, between human Gamma-Glu-X carboxypeptidase and Dihydrofolate reductase from Chlamydia muridarum which collectively metabolize the drug Folic acid, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Methionine synthase reductase (MTRR) Click to Show/Hide the Cometabolization Info
DME ID DME0431 DME Info
Uniprot ID
MTRR_HUMAN
Interaction Name MTRR-folA interaction [1], [2], [6]
Description The interaction, between human Methionine synthase reductase and Dihydrofolate reductase from Chlamydia muridarum which collectively metabolize the drug Folic acid, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Methylenetetrahydrofolate reductase (MTHFR) Click to Show/Hide the Cometabolization Info
DME ID DME0083 DME Info
Uniprot ID
MTHR_HUMAN
Interaction Name MTHFR-folA interaction [1], [2], [7]
Description The interaction, between human Methylenetetrahydrofolate reductase and Dihydrofolate reductase from Chlamydia muridarum which collectively metabolize the drug Folic acid, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            RNA cytidine acetyltransferase (hALP) Click to Show/Hide the Cometabolization Info
DME ID DME0007 DME Info
Uniprot ID
NAT10_HUMAN
Interaction Name hALP-folA interaction [1], [2], [8]
Description The interaction, between human RNA cytidine acetyltransferase and Dihydrofolate reductase from Chlamydia muridarum which collectively metabolize the drug Folic acid, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Vitamin B12 methionine synthase (MTR) Click to Show/Hide the Cometabolization Info
DME ID DME0153 DME Info
Uniprot ID
METH_HUMAN
Interaction Name MTR-folA interaction [1], [2], [9]
Description The interaction, between human Vitamin B12 methionine synthase and Dihydrofolate reductase from Chlamydia muridarum which collectively metabolize the drug Folic acid, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
References
1 Biophysical principles predict fitness landscapes of drug resistance. Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):E1470-8.
2 The Genital tract virulence factor pGP3 is essential for Chlamydia muridarum colonization in the gastrointestinal tract. Infect Immun. 2017 Dec 19;86(1). pii: e00429-17.
3 Chronic ethanol feeding and folate deficiency activate hepatic endoplasmic reticulum stress pathway in micropigs. Am J Physiol Gastrointest Liver Physiol. 2005 Jul;289(1):G54-63.
4 The dihydrofolate reductase 19 bp polymorphism is not associated with biomarkers of folate status in healthy young adults, irrespective of folic acid intake. J Nutr. 2015 Oct;145(10):2207-11.
5 Optimization of the trienzyme extraction for the microbiological assay of folate in vegetables. J Agric Food Chem. 2007 May 16;55(10):3884-8.
6 Polymorphisms in genes involved in folate metabolism as maternal risk factors for Down syndrome in China. J Zhejiang Univ Sci B. 2008 Feb;9(2):93-9.
7 Genetic variation: impact on folate (and choline) bioefficacy. Int J Vitam Nutr Res. 2010 Oct;80(4-5):319-29.
8 Arylamine N-acetyltransferase in human red blood cells. Biochem Pharmacol. 1992 Sep 25;44(6):1099-104.
9 Metabolic derangement of methionine and folate metabolism in mice deficient in methionine synthase reductase. Mol Genet Metab. 2007 May;91(1):85-97.

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