Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1053)
DME Name L-arabinose isomerase (araA), Lactobacillus sakei DME Info
UniProt ID
ARAA_LACSS
EC Number    EC: 5.3.1.4     (Click to Show/Hide the Complete EC Tree)
Isomerase
Intramolecular oxidoreductase
Aldose/ketose isomerase
EC: 5.3.1.4
Lineage    Species: Lactobacillus sakei     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Lactobacillaceae
Genus: Lactobacillus
Species: Lactobacillus sakei
Subspecies: Lactobacillus sakei 23K
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      Drug co-metabolism
               Cometabolized drug: CERC-801 Click to Show/Hide the Full List of HOSPPI:        2 HOSPPI
                            Galactose kinase (GALK1) Click to Show/Hide the Cometabolization Info
DME ID DME0417 DME Info
Uniprot ID
GALK1_HUMAN
Interaction Name GALK1-araA interaction [1], [2]
Description The interaction, between human Galactose kinase and L-arabinose isomerase from Lactobacillus sakei which collectively metabolize the drug CERC-801, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Sulfotransferase 1A1 (SULT1A1) Click to Show/Hide the Cometabolization Info
DME ID DME0008 DME Info
Uniprot ID
ST1A1_HUMAN
Interaction Name SULT1A1-araA interaction [1], [3]
Description The interaction, between human Sulfotransferase 1A1 and L-arabinose isomerase from Lactobacillus sakei which collectively metabolize the drug CERC-801, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
References
1 The acid tolerant L-arabinose isomerase from the food grade Lactobacillus sakei 23K is an attractive D-tagatose producer. Bioresour Technol. 2010 Dec;101(23):9171-7.
2 Molecular and biochemical characterization of human galactokinase and its small molecule inhibitors. Chem Biol Interact. 2010 Dec 5;188(3):376-85.
3 Sulfation of the galactose residues in the glycosaminoglycan-protein linkage region by recombinant human chondroitin 6-O-sulfotransferase-1. J Biol Chem. 2008 Oct 10;283(41):27438-43.

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