Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1058)
DME Name	Propanediol dehydrogenase (dhaT), Lactobacillus brevis	DME Info
UniProt ID	A0A0C1Q6R1_LACBR
EC Number	EC: 1.1.1.202 (Click to Show/Hide the Complete EC Tree) Oxidoreductase CH-OH donor oxidoreductase NAD/NADP oxidoreductase EC: 1.1.1.202
Lineage	Species: Lactobacillus brevis (Click to Show/Hide the Complete Species Lineage) Kingdom: Bacteria Phylum: Firmicutes Class: Bacilli Order: Lactobacillales Family: Lactobacillaceae Genus: Lactobacillus Species: Lactobacillus brevis Subspecies: Lactobacillus brevis 6239 Subspecies: Lactobacillus brevis B22
Interactome

Disease Specific Interactions between Host Protein and DME (HOSPPI)
Drug co-metabolism
Cometabolized drug: Glycerol		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
Aquaporin adipose (AQP7)		Click to Show/Hide the Cometabolization Info
DME ID	DME0407 DME Info
Uniprot ID	AQP7_HUMAN
Interaction Name	AQP7-dhaT interaction		[1], [2]
Description	The interaction, between human Aquaporin adipose and Propanediol dehydrogenase from Lactobacillus brevis which collectively metabolize the drug Glycerol, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.

References
1	Expression and characterization of a novel 1,3-propanediol dehydrogenase from Lactobacillus brevis. Appl Biochem Biotechnol. 2016 Jul;179(6):959-72.
2	Aquaporins in the human testis and spermatozoa - identification, involvement in sperm volume regulation and clinical relevance. Int J Androl. 2010 Aug 1;33(4):629-41.

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