Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1068)
DME Name Aminoglycoside O-phosphotransferase (aphA6), Acinetobacter baumannii DME Info
UniProt ID
KKA6_ACIBA
EC Number    EC: 2.7.1.95     (Click to Show/Hide the Complete EC Tree)
Transferase
Kinase
Phosphotransferase
EC: 2.7.1.95
Lineage    Species: Acinetobacter baumannii     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Pseudomonadales
Family: Moraxellaceae
Genus: Acinetobacter
Species: Acinetobacter baumannii
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      Drug co-metabolism
               Cometabolized drug: Tobramycin Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                            RNA cytidine acetyltransferase (hALP) Click to Show/Hide the Cometabolization Info
DME ID DME0007 DME Info
Uniprot ID
NAT10_HUMAN
Interaction Name hALP-aphA6 interaction [1], [2]
Description The interaction, between human RNA cytidine acetyltransferase and Aminoglycoside O-phosphotransferase from Acinetobacter baumannii which collectively metabolize the drug Tobramycin, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
               Cometabolized drug: Netilmicin Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                            RNA cytidine acetyltransferase (hALP) Click to Show/Hide the Cometabolization Info
DME ID DME0007 DME Info
Uniprot ID
NAT10_HUMAN
Interaction Name hALP-aphA6 interaction [1], [3]
Description The interaction, between human RNA cytidine acetyltransferase and Aminoglycoside O-phosphotransferase from Acinetobacter baumannii which collectively metabolize the drug Netilmicin, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
References
1 Relationship between antimicrobial resistance and aminoglycoside-modifying enzyme gene expressions in Acinetobacter baumannii. Chin Med J (Engl). 2005 Jan 20;118(2):141-5.
2 Genetic analysis of bacterial acetyltransferases: identification of amino acids determining the specificities of the aminoglycoside 6'-N-acetyltransferase Ib and IIa proteins. J Bacteriol. 1992 May;174(10):3196-203.
3 Aminoglycoside resistance resulting from tight drug binding to an altered aminoglycoside acetyltransferase. Antimicrob Agents Chemother. 2003 May;47(5):1577-83.

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