| General Information of Drug-Metabolizing Enzyme (DME ID: DME1085) |
| DME Name |
VanA ligase (vanA), Enterococcus faecalis
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DME Info
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| UniProt ID |
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| EC Number |
EC: 6.3.2.4 (Click to Show/Hide the Complete EC Tree)
Ligase
Carbon-nitrogen ligase
Peptide synthase
EC: 6.3.2.4
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| Lineage |
Species: Enterococcus faecalis (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Enterococcaceae
Genus: Enterococcus
Species: Enterococcus faecalis
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| Interactome |
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| Disease Specific Interactions between Host Protein and DME (HOSPPI) |
| Drug co-metabolism |
| Cometabolized drug: Teicoplanin |
Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
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| Sulfotransferase 1A1 (SULT1A1) |
Click to Show/Hide the Cometabolization Info |
| DME ID |
DME0008
DME Info
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| Uniprot ID |
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| Interaction Name |
SULT1A1-vanA interaction |
[1], [2] |
| Description |
The interaction, between human Sulfotransferase 1A1 and VanA ligase from Enterococcus faecalis which collectively metabolize the drug Teicoplanin, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism. |
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| References |
| 1 |
Genetics and mechanisms of glycopeptide resistance in enterococci. Antimicrob Agents Chemother. 1993 Aug;37(8):1563-71.
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| 2 |
The 2.7 A resolution structure of the glycopeptide sulfotransferase Teg14. Acta Crystallogr D Biol Crystallogr. 2010 Dec;66(Pt 12):1278-86.
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