Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1090)
DME Name Aminoglycoside phosphotransferase (aph-Ib), Campylobacter jejuni DME Info
UniProt ID
A0A075C7U3_CAMJU
EC Number    EC: 2.7.1.190     (Click to Show/Hide the Complete EC Tree)
Transferase
Kinase
Phosphotransferase
EC: 2.7.1.190
Lineage    Species: Campylobacter jejuni     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Epsilonproteobacteria
Order: Campylobacterales
Family: Campylobacteraceae
Genus: Campylobacter
Species: Campylobacter jejuni
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      Drug co-metabolism
               Cometabolized drug: Tobramycin Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                            RNA cytidine acetyltransferase (hALP) Click to Show/Hide the Cometabolization Info
DME ID DME0007 DME Info
Uniprot ID
NAT10_HUMAN
Interaction Name hALP-aph-Ib interaction [1], [2]
Description The interaction, between human RNA cytidine acetyltransferase and Aminoglycoside phosphotransferase from Campylobacter jejuni which collectively metabolize the drug Tobramycin, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
References
1 Cloning and expression of novel aminoglycoside phosphotransferase genes from Campylobacter and their role in the resistance to six aminoglycosides. Antimicrob Agents Chemother. 2017 Dec 21;62(1). pii: e01682-17.
2 Genetic analysis of bacterial acetyltransferases: identification of amino acids determining the specificities of the aminoglycoside 6'-N-acetyltransferase Ib and IIa proteins. J Bacteriol. 1992 May;174(10):3196-203.

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