Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1090)
DME Name	Aminoglycoside phosphotransferase (aph-Ib), Campylobacter jejuni	DME Info
UniProt ID	A0A075C7U3_CAMJU
EC Number	EC: 2.7.1.190 (Click to Show/Hide the Complete EC Tree) Transferase Kinase Phosphotransferase EC: 2.7.1.190
Lineage	Species: Campylobacter jejuni (Click to Show/Hide the Complete Species Lineage) Kingdom: Bacteria Phylum: Proteobacteria Class: Epsilonproteobacteria Order: Campylobacterales Family: Campylobacteraceae Genus: Campylobacter Species: Campylobacter jejuni
Interactome

Disease Specific Interactions between Host Protein and DME (HOSPPI)
Drug co-metabolism
Cometabolized drug: Tobramycin		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
RNA cytidine acetyltransferase (hALP)		Click to Show/Hide the Cometabolization Info
DME ID	DME0007 DME Info
Uniprot ID	NAT10_HUMAN
Interaction Name	hALP-aph-Ib interaction		[1], [2]
Description	The interaction, between human RNA cytidine acetyltransferase and Aminoglycoside phosphotransferase from Campylobacter jejuni which collectively metabolize the drug Tobramycin, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.

References
1	Cloning and expression of novel aminoglycoside phosphotransferase genes from Campylobacter and their role in the resistance to six aminoglycosides. Antimicrob Agents Chemother. 2017 Dec 21;62(1). pii: e01682-17.
2	Genetic analysis of bacterial acetyltransferases: identification of amino acids determining the specificities of the aminoglycoside 6'-N-acetyltransferase Ib and IIa proteins. J Bacteriol. 1992 May;174(10):3196-203.

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