Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1091)
DME Name	Kanamycin/gentamycin-resistance enzyme (aacA), Campylobacter coli	DME Info
UniProt ID	J3S7E2_CAMCO
EC Number	EC: 2.7.1.190 (Click to Show/Hide the Complete EC Tree) Transferase Kinase Phosphotransferase EC: 2.7.1.190
Lineage	Species: Campylobacter coli (Click to Show/Hide the Complete Species Lineage) Kingdom: Bacteria Phylum: Proteobacteria Class: Epsilonproteobacteria Order: Campylobacterales Family: Campylobacteraceae Genus: Campylobacter Species: Campylobacter coli
Interactome

Disease Specific Interactions between Host Protein and DME (HOSPPI)
Drug co-metabolism
Cometabolized drug: Tobramycin		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
RNA cytidine acetyltransferase (hALP)		Click to Show/Hide the Cometabolization Info
DME ID	DME0007 DME Info
Uniprot ID	NAT10_HUMAN
Interaction Name	hALP-aacA interaction		[1], [2]
Description	The interaction, between human RNA cytidine acetyltransferase and Kanamycin/gentamycin-resistance enzyme from Campylobacter coli which collectively metabolize the drug Tobramycin, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.

References
1	Cloning and expression of novel aminoglycoside phosphotransferase genes from Campylobacter and their role in the resistance to six aminoglycosides. Antimicrob Agents Chemother. 2017 Dec 21;62(1). pii: e01682-17.
2	Genetic analysis of bacterial acetyltransferases: identification of amino acids determining the specificities of the aminoglycoside 6'-N-acetyltransferase Ib and IIa proteins. J Bacteriol. 1992 May;174(10):3196-203.

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