Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1094)
DME Name Beta-lactamase (blaB), Citrobacter freundii DME Info
UniProt ID
AMPC_CITFR
EC Number    EC: 3.5.2.6     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Carbon-nitrogen hydrolase
Cyclic amide hydrolase
EC: 3.5.2.6
Lineage    Species: Citrobacter freundii     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Enterobacteriaceae
Genus: Citrobacter
Species: Citrobacter freundii
Subspecies: Citrobacter freundii ATCC 6879
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      Drug co-metabolism
               Cometabolized drug: Amoxicillin Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                            Mephenytoin 4-hydroxylase (CYP2C19) Click to Show/Hide the Cometabolization Info
DME ID DME0021 DME Info
Uniprot ID
CP2CJ_HUMAN
Interaction Name CYP2C19-blaB interaction [1], [2]
Description The interaction, between human Mephenytoin 4-hydroxylase and Beta-lactamase from Citrobacter freundii which collectively metabolize the drug Amoxicillin, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
               Cometabolized drug: Cefazolin Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                            Thiopurine methyltransferase (TPMT) Click to Show/Hide the Cometabolization Info
DME ID DME0014 DME Info
Uniprot ID
TPMT_HUMAN
Interaction Name TPMT-blaB interaction [3], [4], [5]
Description The interaction, between human Thiopurine methyltransferase and Beta-lactamase from Citrobacter freundii which collectively metabolize the drug Cefazolin, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
References
1 Detection and characterization of beta-lactamase genes in subgingival bacteria from patients with refractory periodontitis. FEMS Microbiol Lett. 2005 Jan 15;242(2):319-24.
2 High-dose rabeprazole/amoxicillin therapy as the second-line regimen after failure to eradicate H. pylori by triple therapy with the usual doses of a proton pump inhibitor, clarithromycin and amoxicillin. Hepatogastroenterology. 2003 Nov-Dec;50(54):2274-8.
3 Citrobacter freundii bacteremia: Risk factors of mortality and prevalence of resistance genes. J Microbiol Immunol Infect. 2018 Aug;51(4):565-572.
4 Identification and functional characterization of arylamine N-acetyltransferases in eubacteria: evidence for highly selective acetylation of 5-aminosalicylic acid. J Bacteriol. 2001 Jun;183(11):3417-27.
5 Cefazolin administration and 2-methyl-1,3,4-thiadiazole-5-thiol in human tissue: possible relationship to hypoprothrombinemia. Drug Metab Dispos. 2002 Oct;30(10):1123-8.

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