Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1095)
DME Name Beta-lactamase (blaB), Bacteroides fragilis DME Info
UniProt ID
BLAB_BACFG
EC Number    EC: 3.5.2.6     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Carbon-nitrogen hydrolase
Cyclic amide hydrolase
EC: 3.5.2.6
Lineage    Species: Bacteroides fragilis     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Bacteroidetes
Class: Bacteroidia
Order: Bacteroidales
Family: Bacteroidaceae
Genus: Bacteroides
Species: Bacteroides fragilis
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      Drug co-metabolism
               Cometabolized drug: Amoxicillin Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                            Mephenytoin 4-hydroxylase (CYP2C19) Click to Show/Hide the Cometabolization Info
DME ID DME0021 DME Info
Uniprot ID
CP2CJ_HUMAN
Interaction Name CYP2C19-blaB interaction [1], [2]
Description The interaction, between human Mephenytoin 4-hydroxylase and Beta-lactamase from Bacteroides fragilis which collectively metabolize the drug Amoxicillin, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
               Cometabolized drug: Cefazolin Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                            Thiopurine methyltransferase (TPMT) Click to Show/Hide the Cometabolization Info
DME ID DME0014 DME Info
Uniprot ID
TPMT_HUMAN
Interaction Name TPMT-blaB interaction [1], [3], [4]
Description The interaction, between human Thiopurine methyltransferase and Beta-lactamase from Bacteroides fragilis which collectively metabolize the drug Cefazolin, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
References
1 Prevalence of antimicrobial resistance genes in Bacteroides spp. and Prevotella spp. Dutch clinical isolates. Clin Microbiol Infect. 2019 Sep;25(9):1156.e9-1156.e13.
2 High-dose rabeprazole/amoxicillin therapy as the second-line regimen after failure to eradicate H. pylori by triple therapy with the usual doses of a proton pump inhibitor, clarithromycin and amoxicillin. Hepatogastroenterology. 2003 Nov-Dec;50(54):2274-8.
3 Antibacterial activity of cefoperazone against anaerobic bacteria (author's transl). Jpn J Antibiot. 1980 Nov;33(11):1171-82.
4 Cefazolin administration and 2-methyl-1,3,4-thiadiazole-5-thiol in human tissue: possible relationship to hypoprothrombinemia. Drug Metab Dispos. 2002 Oct;30(10):1123-8.

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