General Information of Drug-Metabolizing Enzyme (DME ID: DME1096)
DME Name Azoreductase (azoR), Escherichia coli DME Info
UniProt ID
AZOR_ECOLI
EC Number    EC: 1.7.1.6     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Cytochrome acceptor oxidoreductase
NAD/NADP acceptor oxidoreductase
EC: 1.7.1.6
Lineage    Species: Escherichia coli     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Enterobacteriaceae
Genus: Escherichia
Species: Escherichia coli
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      Drug co-metabolism
               Cometabolized drug: CBL-954 Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                            Quinone reductase 1 (NQO1) Click to Show/Hide the Cometabolization Info
DME ID DME0097 DME Info
Uniprot ID
NQO1_HUMAN
Interaction Name NQO1-azoR interaction [1], [2]
Description The interaction, between human Quinone reductase 1 and Azoreductase from Escherichia coli which collectively metabolize the drug CBL-954, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
References
1 Discovery and evaluation of Escherichia coli nitroreductases that activate the anti-cancer prodrug CB1954. Biochem Pharmacol. 2010 Mar 1;79(5):678-87.
2 Gene Therapy of the Central Nervous System. Charter 22 - Prodrug-Activation Gene Therapy. 2006, Pages 291-301

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