Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1097)
DME Name	N-ethylmaleimide reductase (nemA), Escherichia coli	DME Info
UniProt ID	NEMA_ECOLI
EC Number	EC: 1.3.1.- (Click to Show/Hide the Complete EC Tree) Oxidoreductase CH-CH donor oxidoreductase NAD/NADP acceptor oxidoreductase EC: 1.3.1.-
Lineage	Species: Escherichia coli (Click to Show/Hide the Complete Species Lineage) Kingdom: Bacteria Phylum: Proteobacteria Class: Gammaproteobacteria Order: Enterobacterales Family: Enterobacteriaceae Genus: Escherichia Species: Escherichia coli
Interactome

Disease Specific Interactions between Host Protein and DME (HOSPPI)
Drug co-metabolism
Cometabolized drug: CBL-954		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
Quinone reductase 1 (NQO1)		Click to Show/Hide the Cometabolization Info
DME ID	DME0097 DME Info
Uniprot ID	NQO1_HUMAN
Interaction Name	NQO1-nemA interaction		[1], [2]
Description	The interaction, between human Quinone reductase 1 and N-ethylmaleimide reductase from Escherichia coli which collectively metabolize the drug CBL-954, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.

References
1	Discovery and evaluation of Escherichia coli nitroreductases that activate the anti-cancer prodrug CB1954. Biochem Pharmacol. 2010 Mar 1;79(5):678-87.
2	Gene Therapy of the Central Nervous System. Charter 22 - Prodrug-Activation Gene Therapy. 2006, Pages 291-301

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