Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1100)
DME Name	Arylamine N-acetyltransferase (NAT), Shigella flexneri	DME Info
UniProt ID	A0A1C3HAL9_SERMA
EC Number	EC: 2.3.1.5 (Click to Show/Hide the Complete EC Tree) Transferase Acyltransferase Acyltransferase EC: 2.3.1.5
Lineage	Species: Shigella flexneri (Click to Show/Hide the Complete Species Lineage) Kingdom: Bacteria Phylum: Proteobacteria Class: Gammaproteobacteria Order: Enterobacterales Family: Enterobacteriaceae Genus: Shigella Species: Shigella flexneri
Interactome

Disease Specific Interactions between Host Protein and DME (HOSPPI)
Drug co-metabolism
Cometabolized drug: Asacolitin		Click to Show/Hide the Full List of HOSPPI: 2 HOSPPI
N-acetyltransferase 1 (NAT1)		Click to Show/Hide the Cometabolization Info
DME ID	DME0050 DME Info
Uniprot ID	ARY1_HUMAN
Interaction Name	NAT1-NAT interaction		[1], [1]
Description	The interaction, between human N-acetyltransferase 1 and Arylamine N-acetyltransferase from Shigella flexneri which collectively metabolize the drug Asacolitin, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
N-acetyltransferase 2 (NAT2)		Click to Show/Hide the Cometabolization Info
DME ID	DME0051 DME Info
Uniprot ID	ARY2_HUMAN
Interaction Name	NAT2-NAT interaction		[1], [1]
Description	The interaction, between human N-acetyltransferase 2 and Arylamine N-acetyltransferase from Shigella flexneri which collectively metabolize the drug Asacolitin, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.

References
1	Identification and functional characterization of arylamine N-acetyltransferases in eubacteria: evidence for highly selective acetylation of 5-aminosalicylic acid. J Bacteriol. 2001 Jun;183(11):3417-27.

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