General Information of Drug-Metabolizing Enzyme (DME ID: DME1100)
DME Name Arylamine N-acetyltransferase (NAT), Shigella flexneri DME Info
UniProt ID
A0A1C3HAL9_SERMA
EC Number    EC: 2.3.1.5     (Click to Show/Hide the Complete EC Tree)
Transferase
Acyltransferase
Acyltransferase
EC: 2.3.1.5
Lineage    Species: Shigella flexneri     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Enterobacteriaceae
Genus: Shigella
Species: Shigella flexneri
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      Drug co-metabolism
               Cometabolized drug: Asacolitin Click to Show/Hide the Full List of HOSPPI:        2 HOSPPI
                            N-acetyltransferase 1 (NAT1) Click to Show/Hide the Cometabolization Info
DME ID DME0050 DME Info
Uniprot ID
ARY1_HUMAN
Interaction Name NAT1-NAT interaction [1], [1]
Description The interaction, between human N-acetyltransferase 1 and Arylamine N-acetyltransferase from Shigella flexneri which collectively metabolize the drug Asacolitin, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            N-acetyltransferase 2 (NAT2) Click to Show/Hide the Cometabolization Info
DME ID DME0051 DME Info
Uniprot ID
ARY2_HUMAN
Interaction Name NAT2-NAT interaction [1], [1]
Description The interaction, between human N-acetyltransferase 2 and Arylamine N-acetyltransferase from Shigella flexneri which collectively metabolize the drug Asacolitin, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
References
1 Identification and functional characterization of arylamine N-acetyltransferases in eubacteria: evidence for highly selective acetylation of 5-aminosalicylic acid. J Bacteriol. 2001 Jun;183(11):3417-27.

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