Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1112)
DME Name Carboxylic ester hydrolase (CEH), Butyrivibrio fibrisolvens DME Info
UniProt ID
A0A317G4I6_BUTFI
EC Number    EC: 3.1.1.1     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Ester bond hydrolase
Carboxylic ester hydrolase
EC: 3.1.1.1
Lineage    Species: Butyrivibrio fibrisolvens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Lachnospiraceae
Genus: Butyrivibrio
Species: Butyrivibrio fibrisolvens
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      Drug co-metabolism
               Cometabolized drug: Alpha-linolenic acid Click to Show/Hide the Full List of HOSPPI:        2 HOSPPI
                            Prostaglandin G/H synthase 1 (COX-1) Click to Show/Hide the Cometabolization Info
DME ID DME0091 DME Info
Uniprot ID
PGH1_HUMAN
Interaction Name COX-1-CEH interaction [1], [2], [3]
Description The interaction, between human Prostaglandin G/H synthase 1 and Carboxylic ester hydrolase from Butyrivibrio fibrisolvens which collectively metabolize the drug Alpha-linolenic acid, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Prostaglandin G/H synthase 2 (COX-2) Click to Show/Hide the Cometabolization Info
DME ID DME0114 DME Info
Uniprot ID
PGH2_HUMAN
Interaction Name COX-2-CEH interaction [1], [2], [3]
Description The interaction, between human Prostaglandin G/H synthase 2 and Carboxylic ester hydrolase from Butyrivibrio fibrisolvens which collectively metabolize the drug Alpha-linolenic acid, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
References
1 Immunogenic inhibition of prominent ruminal bacteria as a means to reduce lipolysis and biohydrogenation activity in vitro. Food Chem. 2017 Mar 1;218:372-377.
2 Cell-associated alpha-amylases of butyrate-producing Firmicute bacteria from the human colon. Microbiology. 2006 Nov;152(Pt 11):3281-3290.
3 Divergent cyclooxygenase responses to fatty acid structure and peroxide level in fish and mammalian prostaglandin H synthases. FASEB J. 2006 Jun;20(8):1097-108.

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