Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1115)
DME Name S-adenosylhomocysteine nucleosidase (mtnN), Klebsiella pneumoniae DME Info
UniProt ID
MTNN_KLEPN
EC Number    EC: 3.2.2.9     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Glycosylase
N-Glycosyl compound glycosidase
EC: 3.2.2.9
Lineage    Species: Klebsiella pneumoniae     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Enterobacteriaceae
Genus: Klebsiella
Species: Klebsiella pneumoniae
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      Drug co-metabolism
               Cometabolized drug: Methylthioadenosine Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                            S-methyl-5'-thioadenosine phosphorylase (MTAP) Click to Show/Hide the Cometabolization Info
DME ID DME0464 DME Info
Uniprot ID
MTAP_HUMAN
Interaction Name MTAP-mtnN interaction [1], [2]
Description The interaction, between human S-methyl-5'-thioadenosine phosphorylase and S-adenosylhomocysteine nucleosidase from Klebsiella pneumoniae which collectively metabolize the drug Methylthioadenosine, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
References
1 Selective killing of Klebsiella pneumoniae by 5-trifluoromethylthioribose. Chemotherapeutic exploitation of the enzyme 5-methylthioribose kinase. J Biol Chem. 1990 Jan 15;265(2):831-7.
2 Picomolar transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylase and X-ray structure with MT-immucillin-A. Biochemistry. 2004 Jan 13;43(1):9-18.

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