| General Information of Drug-Metabolizing Enzyme (DME ID: DME1130) |
| DME Name |
Cellobiose 2-epimerase (CE), Eubacterium siraeum
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DME Info
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| UniProt ID |
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| EC Number |
EC: 5.1.3.11 (Click to Show/Hide the Complete EC Tree)
Isomerase
Racemase/epimerase
Carbohydrate racemase/epimerase
EC: 5.1.3.11
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| Lineage |
Species: Eubacterium siraeum (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Ruminococcaceae
Genus: Eubacterium
Species: Eubacterium siraeum
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| Interactome |
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| Disease Specific Interactions between Host Protein and DME (HOSPPI) |
| Drug co-metabolism |
| Cometabolized drug: M-7403 |
Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
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| Sucrase-isomaltase intestinal (SI) |
Click to Show/Hide the Cometabolization Info |
| DME ID |
DME0457
DME Info
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| Uniprot ID |
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| Interaction Name |
SI-CE interaction |
[1], [2] |
| Description |
The interaction, between human Sucrase-isomaltase intestinal and Cellobiose 2-epimerase from Eubacterium siraeum which collectively metabolize the drug M-7403, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism. |
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| References |
| 1 |
Cloning and sequencing of the gene for cellobiose 2-epimerase from a ruminal strain of Eubacterium cellulosolvens. FEMS Microbiol Lett. 2008 Oct;287(1):34-40.
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| 2 |
Structural basis for substrate selectivity in human maltase-glucoamylase and sucrase-isomaltase N-terminal domains. J Biol Chem. 2010 Jun 4;285(23):17763-70.
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