Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1136)
DME Name Fructokinase (scrK), Fusobacterium mortiferum DME Info
UniProt ID
SCRK_FUSMR
EC Number    EC: 2.7.1.4     (Click to Show/Hide the Complete EC Tree)
Transferase
Kinase
Phosphotransferase
EC: 2.7.1.4
Lineage    Species: Fusobacterium mortiferum     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Fusobacteria
Class: Fusobacteriia
Order: Fusobacteriales
Family: Fusobacteriaceae
Genus: Fusobacterium
Species: Fusobacterium mortiferum
Subspecies: Fusobacterium mortiferum ATCC 25557
Subspecies: Fusobacterium mortiferum ATCC 9817
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      Drug co-metabolism
               Cometabolized drug: M-7403 Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                            Sucrase-isomaltase intestinal (SI) Click to Show/Hide the Cometabolization Info
DME ID DME0457 DME Info
Uniprot ID
SUIS_HUMAN
Interaction Name SI-scrK interaction [1], [2], [3]
Description The interaction, between human Sucrase-isomaltase intestinal and Fructokinase from Fusobacterium mortiferum which collectively metabolize the drug M-7403, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
References
1 Sugar metabolism by fusobacteria: regulation of transport, phosphorylation, and polymer formation by Fusobacterium mortiferum ATCC 25557. Infect Immun. 1991 Dec;59(12):4547-54.
2 Clinical Fusobacterium mortiferum isolates cluster with undifferentiated Clostridium rectum species based on 16S rRNA gene phylogenetic analysis. Ann Clin Lab Sci. 2016 May;46(3):279-81.
3 Structural basis for substrate selectivity in human maltase-glucoamylase and sucrase-isomaltase N-terminal domains. J Biol Chem. 2010 Jun 4;285(23):17763-70.

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