| General Information of Drug-Metabolizing Enzyme (DME ID: DME1138) |
| DME Name |
Alpha-glucosidase (aglA), Blautia obeum
|
DME Info
|
| UniProt ID |
|
| EC Number |
EC: 3.2.1.20 (Click to Show/Hide the Complete EC Tree)
Hydrolases
Glycosylase
O/S-glycosyl compound glycosidase
EC: 3.2.1.20
|
| Lineage |
Species: Blautia obeum (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Lachnospiraceae
Genus: Blautia
Species: Blautia obeum
|
| Interactome |
|
| Disease Specific Interactions between Host Protein and DME (HOSPPI) |
| Drug co-metabolism |
| Cometabolized drug: M-7403 |
Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
|
| Sucrase-isomaltase intestinal (SI) |
Click to Show/Hide the Cometabolization Info |
| DME ID |
DME0457
DME Info
|
| Uniprot ID |
|
| Interaction Name |
SI-aglA interaction |
[1], [2] |
| Description |
The interaction, between human Sucrase-isomaltase intestinal and Alpha-glucosidase from Blautia obeum which collectively metabolize the drug M-7403, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism. |
|
|
|
|
|
|
| References |
| 1 |
Novel alpha-glucosidase from human gut microbiome: substrate specificities and their switch. FASEB J. 2010 Oct;24(10):3939-49.
|
| 2 |
Structural basis for substrate selectivity in human maltase-glucoamylase and sucrase-isomaltase N-terminal domains. J Biol Chem. 2010 Jun 4;285(23):17763-70.
|
If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.
