General Information of Drug-Metabolizing Enzyme (DME ID: DME1230)
DME Name Beta-lactamase (blaB), Prevotella nigrescens DME Info
UniProt ID
A0A246EJV2_9BACT
EC Number    EC: 3.5.2.6     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Carbon-nitrogen hydrolase
Cyclic amide hydrolase
EC: 3.5.2.6
Lineage    Species: Prevotella nigrescens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Bacteroidetes
Class: Bacteroidia
Order: Bacteroidales
Family: Prevotellaceae
Genus: Prevotella
Species: Prevotella nigrescens
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      Drug co-metabolism
               Cometabolized drug: Amoxicillin Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                            Mephenytoin 4-hydroxylase (CYP2C19) Click to Show/Hide the Cometabolization Info
DME ID DME0021 DME Info
Uniprot ID
CP2CJ_HUMAN
Interaction Name CYP2C19-blaB interaction [1], [2], [3]
Description The interaction, between human Mephenytoin 4-hydroxylase and Beta-lactamase from Prevotella nigrescens which collectively metabolize the drug Amoxicillin, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
References
1 Prevotella strains and lactamic resistance gene distribution in different oral environments of children with pulp necrosis. Int Endod J. 2018 Nov;51(11):1196-1204.
2 Detection and characterization of beta-lactamase genes in subgingival bacteria from patients with refractory periodontitis. FEMS Microbiol Lett. 2005 Jan 15;242(2):319-24.
3 High-dose rabeprazole/amoxicillin therapy as the second-line regimen after failure to eradicate H. pylori by triple therapy with the usual doses of a proton pump inhibitor, clarithromycin and amoxicillin. Hepatogastroenterology. 2003 Nov-Dec;50(54):2274-8.

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