| General Information of Drug-Metabolizing Enzyme (DME ID: DME1230) |
| DME Name |
Beta-lactamase (blaB), Prevotella nigrescens
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DME Info
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| UniProt ID |
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| EC Number |
EC: 3.5.2.6 (Click to Show/Hide the Complete EC Tree)
Hydrolases
Carbon-nitrogen hydrolase
Cyclic amide hydrolase
EC: 3.5.2.6
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| Lineage |
Species: Prevotella nigrescens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Bacteroidetes
Class: Bacteroidia
Order: Bacteroidales
Family: Prevotellaceae
Genus: Prevotella
Species: Prevotella nigrescens
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| Interactome |
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| Disease Specific Interactions between Host Protein and DME (HOSPPI) |
| Drug co-metabolism |
| Cometabolized drug: Amoxicillin |
Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
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| Mephenytoin 4-hydroxylase (CYP2C19) |
Click to Show/Hide the Cometabolization Info |
| DME ID |
DME0021
DME Info
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| Uniprot ID |
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| Interaction Name |
CYP2C19-blaB interaction |
[1], [2], [3] |
| Description |
The interaction, between human Mephenytoin 4-hydroxylase and Beta-lactamase from Prevotella nigrescens which collectively metabolize the drug Amoxicillin, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism. |
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| References |
| 1 |
Prevotella strains and lactamic resistance gene distribution in different oral environments of children with pulp necrosis. Int Endod J. 2018 Nov;51(11):1196-1204.
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| 2 |
Detection and characterization of beta-lactamase genes in subgingival bacteria from patients with refractory periodontitis. FEMS Microbiol Lett. 2005 Jan 15;242(2):319-24.
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| 3 |
High-dose rabeprazole/amoxicillin therapy as the second-line regimen after failure to eradicate H. pylori by triple therapy with the usual doses of a proton pump inhibitor, clarithromycin and amoxicillin. Hepatogastroenterology. 2003 Nov-Dec;50(54):2274-8.
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