Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1239)
DME Name Folylpolyglutamate synthetase (fpgS), Lactobacillus casei DME Info
UniProt ID
FPGS_LACCA
EC Number    EC: 6.3.2.17     (Click to Show/Hide the Complete EC Tree)
Ligase
Carbon-nitrogen ligase
Peptide synthase
EC: 6.3.2.17
Lineage    Species: Lactobacillus casei     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Lactobacillaceae
Genus: Lactobacillus
Species: Lactobacillus casei
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      Drug co-metabolism
               Cometabolized drug: L-glutamine Click to Show/Hide the Full List of HOSPPI:      18 HOSPPI
                            Asparagine synthetase (ASNS) Click to Show/Hide the Cometabolization Info
DME ID DME0154 DME Info
Uniprot ID
ASNS_HUMAN
Interaction Name ASNS-fpgS interaction [1], [2]
Description The interaction, between human Asparagine synthetase and Folylpolyglutamate synthetase from Lactobacillus casei which collectively metabolize the drug L-glutamine, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Glutamate-cysteine ligase catalytic (GCLC) Click to Show/Hide the Cometabolization Info
DME ID DME0485 DME Info
Uniprot ID
GSH1_HUMAN
Interaction Name GCLC-fpgS interaction [1], [6]
Description The interaction, between human Glutamate-cysteine ligase catalytic and Folylpolyglutamate synthetase from Lactobacillus casei which collectively metabolize the drug L-glutamine, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Glutamate-cysteine ligase regulatory (GCLM) Click to Show/Hide the Cometabolization Info
DME ID DME0486 DME Info
Uniprot ID
GSH0_HUMAN
Interaction Name GCLM-fpgS interaction [1], [7]
Description The interaction, between human Glutamate-cysteine ligase regulatory and Folylpolyglutamate synthetase from Lactobacillus casei which collectively metabolize the drug L-glutamine, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Glutamine amidotransferase (GMPS) Click to Show/Hide the Cometabolization Info
DME ID DME0159 DME Info
Uniprot ID
GUAA_HUMAN
Interaction Name GMPS-fpgS interaction [1], [8]
Description The interaction, between human Glutamine amidotransferase and Folylpolyglutamate synthetase from Lactobacillus casei which collectively metabolize the drug L-glutamine, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Glutamine-dependent NAD(+) synthetase (NADSYN1) Click to Show/Hide the Cometabolization Info
DME ID DME0155 DME Info
Uniprot ID
NADE_HUMAN
Interaction Name NADSYN1-fpgS interaction [1], [9]
Description The interaction, between human Glutamine-dependent NAD(+ synthetase and Folylpolyglutamate synthetase from Lactobacillus casei which collectively metabolize the drug L-glutamine, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Glutaminyl-tRNA synthetase (GLNRS) Click to Show/Hide the Cometabolization Info
DME ID DME0157 DME Info
Uniprot ID
SYQ_HUMAN
Interaction Name GLNRS-fpgS interaction [1], [10]
Description The interaction, between human Glutaminyl-tRNA synthetase and Folylpolyglutamate synthetase from Lactobacillus casei which collectively metabolize the drug L-glutamine, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Glutamyl-tRNA(Gln) amidotransferase B (GATB) Click to Show/Hide the Cometabolization Info
DME ID DME0158 DME Info
Uniprot ID
GATB_HUMAN
Interaction Name GATB-fpgS interaction [1], [11]
Description The interaction, between human Glutamyl-tRNA(Gln amidotransferase B and Folylpolyglutamate synthetase from Lactobacillus casei which collectively metabolize the drug L-glutamine, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Hexosephosphate aminotransferase 2 (GFPT2) Click to Show/Hide the Cometabolization Info
DME ID DME0156 DME Info
Uniprot ID
GFPT2_HUMAN
Interaction Name GFPT2-fpgS interaction [1], [11]
Description The interaction, between human Hexosephosphate aminotransferase 2 and Folylpolyglutamate synthetase from Lactobacillus casei which collectively metabolize the drug L-glutamine, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Kynurenine aminotransferase I (KYAT1) Click to Show/Hide the Cometabolization Info
DME ID DME0160 DME Info
Uniprot ID
KAT1_HUMAN
Interaction Name KYAT1-fpgS interaction [1], [12]
Description The interaction, between human Kynurenine aminotransferase I and Folylpolyglutamate synthetase from Lactobacillus casei which collectively metabolize the drug L-glutamine, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            L-glutamine amidohydrolase (GLS) Click to Show/Hide the Cometabolization Info
DME ID DME0126 DME Info
Uniprot ID
GLSK_HUMAN
Interaction Name GLS-fpgS interaction [1], [13]
Description The interaction, between human L-glutamine amidohydrolase and Folylpolyglutamate synthetase from Lactobacillus casei which collectively metabolize the drug L-glutamine, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            N-acetylglutamate synthase (NAGS) Click to Show/Hide the Cometabolization Info
DME ID DME0534 DME Info
Uniprot ID
NAGS_HUMAN
Interaction Name NAGS-fpgS interaction [1], [16]
Description The interaction, between human N-acetylglutamate synthase and Folylpolyglutamate synthetase from Lactobacillus casei which collectively metabolize the drug L-glutamine, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Phosphoribosylformylglycinamidine synthase (PFAS) Click to Show/Hide the Cometabolization Info
DME ID DME0161 DME Info
Uniprot ID
PUR4_HUMAN
Interaction Name PFAS-fpgS interaction [1], [11]
Description The interaction, between human Phosphoribosylformylglycinamidine synthase and Folylpolyglutamate synthetase from Lactobacillus casei which collectively metabolize the drug L-glutamine, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Transglutaminase E (TGM3) Click to Show/Hide the Cometabolization Info
DME ID DME0165 DME Info
Uniprot ID
TGM3_HUMAN
Interaction Name TGM3-fpgS interaction [1], [11]
Description The interaction, between human Transglutaminase E and Folylpolyglutamate synthetase from Lactobacillus casei which collectively metabolize the drug L-glutamine, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Transglutaminase H (TGM2) Click to Show/Hide the Cometabolization Info
DME ID DME0162 DME Info
Uniprot ID
TGM2_HUMAN
Interaction Name TGM2-fpgS interaction [1], [18]
Description The interaction, between human Transglutaminase H and Folylpolyglutamate synthetase from Lactobacillus casei which collectively metabolize the drug L-glutamine, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Transglutaminase K (TGM1) Click to Show/Hide the Cometabolization Info
DME ID DME0166 DME Info
Uniprot ID
TGM1_HUMAN
Interaction Name TGM1-fpgS interaction [1], [19]
Description The interaction, between human Transglutaminase K and Folylpolyglutamate synthetase from Lactobacillus casei which collectively metabolize the drug L-glutamine, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Transglutaminase X (TGM5) Click to Show/Hide the Cometabolization Info
DME ID DME0163 DME Info
Uniprot ID
TGM5_HUMAN
Interaction Name TGM5-fpgS interaction [1], []
Description The interaction, between human Transglutaminase X and Folylpolyglutamate synthetase from Lactobacillus casei which collectively metabolize the drug L-glutamine, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Transglutaminase Y (TGM6) Click to Show/Hide the Cometabolization Info
DME ID DME0164 DME Info
Uniprot ID
TGM3L_HUMAN
Interaction Name TGM6-fpgS interaction [1], [11]
Description The interaction, between human Transglutaminase Y and Folylpolyglutamate synthetase from Lactobacillus casei which collectively metabolize the drug L-glutamine, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Transglutaminase Z (TGM7) Click to Show/Hide the Cometabolization Info
DME ID DME0167 DME Info
Uniprot ID
TGM7_HUMAN
Interaction Name TGM7-fpgS interaction [1], [11]
Description The interaction, between human Transglutaminase Z and Folylpolyglutamate synthetase from Lactobacillus casei which collectively metabolize the drug L-glutamine, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
               Cometabolized drug: Folic acid Click to Show/Hide the Full List of HOSPPI:        7 HOSPPI
                            Cytochrome P450 2E1 (CYP2E1) Click to Show/Hide the Cometabolization Info
DME ID DME0013 DME Info
Uniprot ID
CP2E1_HUMAN
Interaction Name CYP2E1-fpgS interaction [1], [3]
Description The interaction, between human Cytochrome P450 2E1 and Folylpolyglutamate synthetase from Lactobacillus casei which collectively metabolize the drug Folic acid, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Dihydrofolate reductase (DHFR) Click to Show/Hide the Cometabolization Info
DME ID DME0141 DME Info
Uniprot ID
DYR_HUMAN
Interaction Name DHFR-fpgS interaction [1], [4]
Description The interaction, between human Dihydrofolate reductase and Folylpolyglutamate synthetase from Lactobacillus casei which collectively metabolize the drug Folic acid, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Gamma-Glu-X carboxypeptidase (GGH) Click to Show/Hide the Cometabolization Info
DME ID DME0142 DME Info
Uniprot ID
GGH_HUMAN
Interaction Name GGH-fpgS interaction [1], [5]
Description The interaction, between human Gamma-Glu-X carboxypeptidase and Folylpolyglutamate synthetase from Lactobacillus casei which collectively metabolize the drug Folic acid, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Methionine synthase reductase (MTRR) Click to Show/Hide the Cometabolization Info
DME ID DME0431 DME Info
Uniprot ID
MTRR_HUMAN
Interaction Name MTRR-fpgS interaction [1], [14]
Description The interaction, between human Methionine synthase reductase and Folylpolyglutamate synthetase from Lactobacillus casei which collectively metabolize the drug Folic acid, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Methylenetetrahydrofolate reductase (MTHFR) Click to Show/Hide the Cometabolization Info
DME ID DME0083 DME Info
Uniprot ID
MTHR_HUMAN
Interaction Name MTHFR-fpgS interaction [1], [15]
Description The interaction, between human Methylenetetrahydrofolate reductase and Folylpolyglutamate synthetase from Lactobacillus casei which collectively metabolize the drug Folic acid, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            RNA cytidine acetyltransferase (hALP) Click to Show/Hide the Cometabolization Info
DME ID DME0007 DME Info
Uniprot ID
NAT10_HUMAN
Interaction Name hALP-fpgS interaction [1], [17]
Description The interaction, between human RNA cytidine acetyltransferase and Folylpolyglutamate synthetase from Lactobacillus casei which collectively metabolize the drug Folic acid, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Vitamin B12 methionine synthase (MTR) Click to Show/Hide the Cometabolization Info
DME ID DME0153 DME Info
Uniprot ID
METH_HUMAN
Interaction Name MTR-fpgS interaction [1], [20]
Description The interaction, between human Vitamin B12 methionine synthase and Folylpolyglutamate synthetase from Lactobacillus casei which collectively metabolize the drug Folic acid, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
References
1 Mutagenesis of folylpolyglutamate synthetase indicates that dihydropteroate and tetrahydrofolate bind to the same site. Biochemistry. 2008 Feb 26;47(8):2388-96.
2 A convenient gHMQC-based NMR assay for investigating ammonia channeling in glutamine-dependent amidotransferases: studies of Escherichia coli asparagine synthetase B. Biochemistry. 2007 Apr 24;46(16):4840-9.
3 Chronic ethanol feeding and folate deficiency activate hepatic endoplasmic reticulum stress pathway in micropigs. Am J Physiol Gastrointest Liver Physiol. 2005 Jul;289(1):G54-63.
4 The dihydrofolate reductase 19 bp polymorphism is not associated with biomarkers of folate status in healthy young adults, irrespective of folic acid intake. J Nutr. 2015 Oct;145(10):2207-11.
5 Optimization of the trienzyme extraction for the microbiological assay of folate in vegetables. J Agric Food Chem. 2007 May 16;55(10):3884-8.
6 Kinetic measurement by LC/MS of gamma-glutamylcysteine ligase activity. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Nov 15;827(1):32-8.
7 The enzymes of glutathione synthesis: gamma-glutamylcysteine synthetase. Adv Enzymol Relat Areas Mol Biol. 1999;73:209-67, xii.
8 Thermodynamic characterization of the protein-protein interaction in the heteromeric Bacillus subtilis pyridoxalphosphate synthase. Biochemistry. 2007 May 1;46(17):5131-9.
9 Glutamine-dependent NAD+ synthetase. How a two-domain, three-substrate enzyme avoids waste. J Biol Chem. 2006 Nov 3;281(44):33395-402.
10 Synthesis of beta-ketophosphonate analogs of glutamyl and glutaminyl adenylate, and selective inhibition of the corresponding bacterial aminoacyl-tRNA synthetases. Bioorg Med Chem. 2007 Jan 1;15(1):295-304.
11 How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
12 Determination of kynurenic acid in human serum and its correlation with the concentration of certain amino acids. Clin Chim Acta. 2007 Feb;377(1-2):174-8.
13 Full-length human glutaminase in complex with an allosteric inhibitor. Biochemistry. 2011 Dec 20;50(50):10764-70.
14 Polymorphisms in genes involved in folate metabolism as maternal risk factors for Down syndrome in China. J Zhejiang Univ Sci B. 2008 Feb;9(2):93-9.
15 Genetic variation: impact on folate (and choline) bioefficacy. Int J Vitam Nutr Res. 2010 Oct;80(4-5):319-29.
16 Biochemical properties of recombinant human and mouse N-acetylglutamate synthase. Mol Genet Metab. 2006 Mar;87(3):226-32.
17 Arylamine N-acetyltransferase in human red blood cells. Biochem Pharmacol. 1992 Sep 25;44(6):1099-104.
18 Phage display selection of efficient glutamine-donor substrate peptides for transglutaminase 2. Protein Sci. 2006 Nov;15(11):2466-80.
19 A three-dimensional model of the human transglutaminase 1: insights into the understanding of lamellar ichthyosis. J Mol Model. 2007 Jan;13(1):233-46.
20 Metabolic derangement of methionine and folate metabolism in mice deficient in methionine synthase reductase. Mol Genet Metab. 2007 May;91(1):85-97.

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