Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1241)
DME Name Hyaluronoglucosaminidase (nagH), Treponema vincentii DME Info
UniProt ID
NAGH_CLOPE
EC Number    EC: 3.2.1.35     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Glycosylase
O/S-glycosyl compound glycosidase
EC: 3.2.1.35
Lineage    Species: Treponema vincentii     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Spirochaetes
Class: Spirochaetia
Order: Spirochaetales
Family: Spirochaetaceae
Genus: Treponema
Species: Treponema vincentii
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      Drug co-metabolism
               Cometabolized drug: Chondroitin sulfate Click to Show/Hide the Full List of HOSPPI:        6 HOSPPI
                            Alpha-L-iduronidase (IDUA) Click to Show/Hide the Cometabolization Info
DME ID DME0104 DME Info
Uniprot ID
IDUA_HUMAN
Interaction Name IDUA-nagH interaction [1], [2], [3]
Description The interaction, between human Alpha-L-iduronidase and Hyaluronoglucosaminidase from Treponema vincentii which collectively metabolize the drug Chondroitin sulfate, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Arylsulfatase B (ARSB) Click to Show/Hide the Cometabolization Info
DME ID DME0105 DME Info
Uniprot ID
ARSB_HUMAN
Interaction Name ARSB-nagH interaction [1], [2], [3]
Description The interaction, between human Arylsulfatase B and Hyaluronoglucosaminidase from Treponema vincentii which collectively metabolize the drug Chondroitin sulfate, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Beta-glucuronidase (GUSB) Click to Show/Hide the Cometabolization Info
DME ID DME0106 DME Info
Uniprot ID
BGLR_HUMAN
Interaction Name GUSB-nagH interaction [1], [2], [3]
Description The interaction, between human Beta-glucuronidase and Hyaluronoglucosaminidase from Treponema vincentii which collectively metabolize the drug Chondroitin sulfate, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Chondroitin 6-sulfotransferase (CHST3) Click to Show/Hide the Cometabolization Info
DME ID DME0632 DME Info
Uniprot ID
CHST3_HUMAN
Interaction Name CHST3-nagH interaction [1], [2], [4]
Description The interaction, between human Chondroitin 6-sulfotransferase and Hyaluronoglucosaminidase from Treponema vincentii which collectively metabolize the drug Chondroitin sulfate, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Iduronate 2-sulfatase (IDS) Click to Show/Hide the Cometabolization Info
DME ID DME0108 DME Info
Uniprot ID
IDS_HUMAN
Interaction Name IDS-nagH interaction [1], [2], [3]
Description The interaction, between human Iduronate 2-sulfatase and Hyaluronoglucosaminidase from Treponema vincentii which collectively metabolize the drug Chondroitin sulfate, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            N-acetyl-beta-glucosaminidase beta (HEXB) Click to Show/Hide the Cometabolization Info
DME ID DME0107 DME Info
Uniprot ID
HEXB_HUMAN
Interaction Name HEXB-nagH interaction [1], [2], [3]
Description The interaction, between human N-acetyl-beta-glucosaminidase beta and Hyaluronoglucosaminidase from Treponema vincentii which collectively metabolize the drug Chondroitin sulfate, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
References
1 An extracellular enzyme with hyaluronidase and chondroitinase activities from some oral anaerobic spirochaetes. Microbiology. 1996 Sep;142 ( Pt 9):2567-76.
2 Identification of a Treponema denticola OppA homologue that binds host proteins present in the subgingival environment. Infect Immun. 2000 Apr;68(4):1884-92.
3 MFN human ref: Chondroitin sulfate degradation.
4 Variants in chondroitin sulfate metabolism genes in thrombotic storm. Thromb Res. 2018 Jan;161:43-51.

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