Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1244)
DME Name Nitroreductase (NTR), Clostridium paraputrificum DME Info
UniProt ID
A0A174SJF2_9CLOT
EC Number    EC: 1.5.1.39     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-NH donor oxidoreductase
NAD/NADP acceptor oxidoreductase
EC: 1.5.1.39
Lineage    Species: Clostridium paraputrificum     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Clostridiaceae
Genus: Clostridium
Species: Clostridium paraputrificum
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      Drug co-metabolism
               Cometabolized drug: Nitrofurantoin Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                            NADPH-cytochrome P450 reductase (CPR) Click to Show/Hide the Cometabolization Info
DME ID DME0076 DME Info
Uniprot ID
NCPR_HUMAN
Interaction Name CPR-NTR interaction [1], [2]
Description The interaction, between human NADPH-cytochrome P450 reductase and Nitroreductase from Clostridium paraputrificum which collectively metabolize the drug Nitrofurantoin, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
References
1 Isolation of nitrofurantoin-resistant mutants of nitroreductase-producing Clostridium sp. strains from the human intestinal tract. Antimicrob Agents Chemother. 1998 May;42(5):1121-6.
2 Role of cytochrome P450 reductase in nitrofurantoin-induced redox cycling and cytotoxicity. Free Radic Biol Med. 2008 Mar 15;44(6):1169-79.

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