Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1246)
DME Name	Nitroreductase (NTR), Clostridium hiranonis	DME Info
UniProt ID	A0A351QTB1_CLOSP
EC Number	EC: 1.5.1.39 (Click to Show/Hide the Complete EC Tree) Oxidoreductase CH-NH donor oxidoreductase NAD/NADP acceptor oxidoreductase EC: 1.5.1.39
Lineage	Species: Clostridium hiranonis (Click to Show/Hide the Complete Species Lineage) Kingdom: Bacteria Phylum: Firmicutes Class: Clostridia Order: Clostridiales Family: Peptostreptococcaceae Genus: Clostridium Species: Clostridium hiranonis
Interactome

Disease Specific Interactions between Host Protein and DME (HOSPPI)
Drug co-metabolism
Cometabolized drug: Nitrofurantoin		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
NADPH-cytochrome P450 reductase (CPR)		Click to Show/Hide the Cometabolization Info
DME ID	DME0076 DME Info
Uniprot ID	NCPR_HUMAN
Interaction Name	CPR-NTR interaction		[1], [2]
Description	The interaction, between human NADPH-cytochrome P450 reductase and Nitroreductase from Clostridium hiranonis which collectively metabolize the drug Nitrofurantoin, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.

References
1	Isolation of nitrofurantoin-resistant mutants of nitroreductase-producing Clostridium sp. strains from the human intestinal tract. Antimicrob Agents Chemother. 1998 May;42(5):1121-6.
2	Role of cytochrome P450 reductase in nitrofurantoin-induced redox cycling and cytotoxicity. Free Radic Biol Med. 2008 Mar 15;44(6):1169-79.

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