Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1302)
DME Name	General stress protein 14 (ywrO), Bacillus subtilis	DME Info
UniProt ID	GS14_BACSU
EC Number	EC: 1.6.99.- (Click to Show/Hide the Complete EC Tree) Oxidoreductase NADH/NADPH oxidoreductase Other acceptor oxidoreductase EC: 1.6.99.-
Lineage	Species: Bacillus subtilis (Click to Show/Hide the Complete Species Lineage) Kingdom: Bacteria Phylum: Firmicutes Class: Bacilli Order: Bacillales Family: Bacillaceae Genus: Bacillus Species: Bacillus subtilis
Interactome

Disease Specific Interactions between Host Protein and DME (HOSPPI)
Drug co-metabolism
Cometabolized drug: CBL-954		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
Quinone reductase 1 (NQO1)		Click to Show/Hide the Cometabolization Info
DME ID	DME0097 DME Info
Uniprot ID	NQO1_HUMAN
Interaction Name	NQO1-ywrO interaction		[1], [2]
Description	The interaction, between human Quinone reductase 1 and General stress protein 14 from Bacillus subtilis which collectively metabolize the drug CBL-954, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.

References
1	Bacillus amyloliquefaciens orthologue of Bacillus subtilis ywrO encodes a nitroreductase enzyme which activates the prodrug CB 1954. Microbiology. 2002 Jan;148(Pt 1):297-306.
2	Gene Therapy of the Central Nervous System. Charter 22 - Prodrug-Activation Gene Therapy. 2006, Pages 291-301

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