| General Information of Drug-Metabolizing Enzyme (DME ID: DME1321) |
| DME Name |
Arylamine N-acetyltransferase (NAT), Tsukamurella paurometabola
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DME Info
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| UniProt ID |
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| EC Number |
EC: 2.3.1.5 (Click to Show/Hide the Complete EC Tree)
Transferase
Acyltransferase
Acyltransferase
EC: 2.3.1.5
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| Lineage |
Species: Tsukamurella paurometabola (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Actinobacteria
Class: Actinobacteria
Order: Corynebacteriales
Family: Tsukamurellaceae
Genus: Tsukamurella
Species: Tsukamurella paurometabola
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| Interactome |
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| Disease Specific Interactions between Host Protein and DME (HOSPPI) |
| Drug co-metabolism |
| Cometabolized drug: Isoniazid |
Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
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| Cytochrome P450 2E1 (CYP2E1) |
Click to Show/Hide the Cometabolization Info |
| DME ID |
DME0013
DME Info
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| Uniprot ID |
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| Interaction Name |
CYP2E1-NAT interaction |
[1], [2], [3] |
| Description |
The interaction, between human Cytochrome P450 2E1 and Arylamine N-acetyltransferase from Tsukamurella paurometabola which collectively metabolize the drug Isoniazid, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism. |
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| References |
| 1 |
The actinobacterium Tsukamurella paurometabola has a functionally divergent arylamine N-acetyltransferase (NAT) homolog. World J Microbiol Biotechnol. 2019 Oct 31;35(11):174.
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| 2 |
Complete genome sequence of Tsukamurella paurometabola type strain (no. 33). Stand Genomic Sci. 2011 Jul 1;4(3):342-51.
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| 3 |
Inhibition of CYP2E1 catalytic activity in vitro by S-adenosyl-L-methionine. Biochem Pharmacol. 2005 Apr 1;69(7):1081-93.
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