Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1333)
DME Name	Methylenetetrahydrofolate dehydrogenase (folD), Blautia producta	DME Info
UniProt ID	A0A2S4GHV2_9FIRM
EC Number	EC: 1.5.1.5 (Click to Show/Hide the Complete EC Tree) Oxidoreductase CH-NH donor oxidoreductase NAD/NADP acceptor oxidoreductase EC: 1.5.1.5
Lineage	Species: Blautia producta (Click to Show/Hide the Complete Species Lineage) Kingdom: Bacteria Phylum: Firmicutes Class: Clostridia Order: Clostridiales Family: Lachnospiraceae Genus: Blautia Species: Blautia producta
Interactome

Disease Specific Interactions between Host Protein and DME (HOSPPI)
Drug co-metabolism
Cometabolized drug: ISO-901		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
Methylenetetrahydrofolate reductase (MTHFR)		Click to Show/Hide the Cometabolization Info
DME ID	DME0083 DME Info
Uniprot ID	MTHR_HUMAN
Interaction Name	MTHFR-folD interaction		[1], [2], [3]
Description	The interaction, between human Methylenetetrahydrofolate reductase and Methylenetetrahydrofolate dehydrogenase from Blautia producta which collectively metabolize the drug ISO-901, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.

References
1	Purification and characterization of NADP(+)-dependent 5,10-methylenetetrahydrofolate dehydrogenase from Peptostreptococcus productus marburg. J Bacteriol. 1991 Feb;173(4):1414-9.
2	Characterization of NAD-dependent 3 alpha- and 3 beta-hydroxysteroid dehydrogenase and of NADP-dependent 7 beta-hydroxysteroid dehydrogenase from Peptostreptococcus productus. Biochim Biophys Acta. 1989 Aug 8;1004(2):230-8.
3	Methylenetetrahydrofolate reductase gene polymorphisms: genomic predictors of clinical response to fluoropyrimidine-based chemotherapy? Cancer Chemother Pharmacol. 2006 Jun;57(6):835-40.

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