Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1353)
DME Name Gamma-glutamylcyclotransferase (GGCT), Ralstonia solanacearum DME Info
UniProt ID
A0A073ACX1_RALSL
EC Number    EC: 4.3.2.9     (Click to Show/Hide the Complete EC Tree)
Lyases
Carbon-nitrogen lyase
Amidine-lyase
EC: 4.3.2.9
Lineage    Species: Ralstonia solanacearum     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Betaproteobacteria
Order: Burkholderiales
Family: Burkholderiaceae
Genus: Ralstonia
Species: Ralstonia solanacearum
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      Drug co-metabolism
               Cometabolized drug: ANW-43980 Click to Show/Hide the Full List of HOSPPI:        5 HOSPPI
                            Gamma-glutamylcyclotransferase 2 (CHAC2) Click to Show/Hide the Cometabolization Info
DME ID DME0450 DME Info
Uniprot ID
CHAC2_HUMAN
Interaction Name CHAC2-GGCT interaction [1], [2], [3]
Description The interaction, between human Gamma-glutamylcyclotransferase 2 and Gamma-glutamylcyclotransferase from Ralstonia solanacearum which collectively metabolize the drug ANW-43980, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Gamma-glutamyltranspeptidase 5 (GGT5) Click to Show/Hide the Cometabolization Info
DME ID DME0432 DME Info
Uniprot ID
GGT5_HUMAN
Interaction Name GGT5-GGCT interaction [1], [2], [4]
Description The interaction, between human Gamma-glutamyltranspeptidase 5 and Gamma-glutamylcyclotransferase from Ralstonia solanacearum which collectively metabolize the drug ANW-43980, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Glutathione peroxidase 6 (GPX6) Click to Show/Hide the Cometabolization Info
DME ID DME0610 DME Info
Uniprot ID
GPX6_HUMAN
Interaction Name GPX6-GGCT interaction [1], [2], [5]
Description The interaction, between human Glutathione peroxidase 6 and Gamma-glutamylcyclotransferase from Ralstonia solanacearum which collectively metabolize the drug ANW-43980, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Glutathione S-transferase omega-1 (GSTO1) Click to Show/Hide the Cometabolization Info
DME ID DME0313 DME Info
Uniprot ID
GSTO1_HUMAN
Interaction Name GSTO1-GGCT interaction [1], [2], [6]
Description The interaction, between human Glutathione S-transferase omega-1 and Gamma-glutamylcyclotransferase from Ralstonia solanacearum which collectively metabolize the drug ANW-43980, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Glutathione S-transferase omega-2 (GSTO2) Click to Show/Hide the Cometabolization Info
DME ID DME0314 DME Info
Uniprot ID
GSTO2_HUMAN
Interaction Name GSTO2-GGCT interaction [1], [2], [6]
Description The interaction, between human Glutathione S-transferase omega-2 and Gamma-glutamylcyclotransferase from Ralstonia solanacearum which collectively metabolize the drug ANW-43980, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
References
1 Characterization of the mechanism of thioredoxin-dependent activation of gamma-glutamylcyclotransferase, RipAY, from Ralstonia solanacearum. Biochem Biophys Res Commun. 2020 Mar 12;523(3):759-765.
2 Vaginal microbiome in early pregnancy and subsequent risk of spontaneous preterm birth: a case-control study. BJOG. 2019 Feb;126(3):349-358.
3 ChaC2, an enzyme for slow turnover of cytosolic glutathione. J Biol Chem. 2017 Jan 13;292(2):638-651.
4 Gamma-glutamyl compounds: substrate specificity of gamma-glutamyl transpeptidase enzymes. Anal Biochem. 2011 Jul 15;414(2):208-14.
5 Metabolomics reveals a role for the chromatin-binding protein HMGN5 in glutathione metabolism. PLoS One. 2014 Jan 2;9(1):e84583.
6 Structural insights into the dehydroascorbate reductase activity of human omega-class glutathione transferases. J Mol Biol. 2012 Jul 13;420(3):190-203.

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