Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1461)
DME Name Homoserine-O-transsuccinylase (metAA), Salmonella enterica DME Info
UniProt ID
METAA_THEMA
EC Number    EC: 2.3.1.46     (Click to Show/Hide the Complete EC Tree)
Transferase
Acyltransferase
Acyltransferase
EC: 2.3.1.46
Lineage    Species: Salmonella enterica     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Enterobacteriaceae
Genus: Salmonella
Species: Salmonella enterica
Subspecies: Salmonella enterica subsp. enterica serovar Typhimurium
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      Drug co-metabolism
               Cometabolized drug: Methionine Click to Show/Hide the Full List of HOSPPI:        8 HOSPPI
                            Methionine adenosyltransferase II beta (MAT2B) Click to Show/Hide the Cometabolization Info
DME ID DME0183 DME Info
Uniprot ID
MAT2B_HUMAN
Interaction Name MAT2B-metAA interaction [1], []
Description The interaction, between human Methionine adenosyltransferase II beta and Homoserine-O-transsuccinylase from Salmonella enterica which collectively metabolize the drug Methionine, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Methionine-R-sulfoxide reductase B1 (MSRB1) Click to Show/Hide the Cometabolization Info
DME ID DME0184 DME Info
Uniprot ID
MSRB1_HUMAN
Interaction Name MSRB1-metAA interaction [1], [2]
Description The interaction, between human Methionine-R-sulfoxide reductase B1 and Homoserine-O-transsuccinylase from Salmonella enterica which collectively metabolize the drug Methionine, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Methionine-R-sulfoxide reductase B2 (MSRB2) Click to Show/Hide the Cometabolization Info
DME ID DME0185 DME Info
Uniprot ID
MSRB2_HUMAN
Interaction Name MSRB2-metAA interaction [1], [3]
Description The interaction, between human Methionine-R-sulfoxide reductase B2 and Homoserine-O-transsuccinylase from Salmonella enterica which collectively metabolize the drug Methionine, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Methionine-tRNA ligase cytoplasmic (MARS) Click to Show/Hide the Cometabolization Info
DME ID DME0186 DME Info
Uniprot ID
SYMC_HUMAN
Interaction Name MARS-metAA interaction [1], [4]
Description The interaction, between human Methionine-tRNA ligase cytoplasmic and Homoserine-O-transsuccinylase from Salmonella enterica which collectively metabolize the drug Methionine, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Methionine-tRNA ligase mitochondrial (MARS2) Click to Show/Hide the Cometabolization Info
DME ID DME0187 DME Info
Uniprot ID
SYMM_HUMAN
Interaction Name MARS2-metAA interaction [1], []
Description The interaction, between human Methionine-tRNA ligase mitochondrial and Homoserine-O-transsuccinylase from Salmonella enterica which collectively metabolize the drug Methionine, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Peptide methionine sulfoxide reductase (MSRA) Click to Show/Hide the Cometabolization Info
DME ID DME0188 DME Info
Uniprot ID
MSRA_HUMAN
Interaction Name MSRA-metAA interaction [1], [5]
Description The interaction, between human Peptide methionine sulfoxide reductase and Homoserine-O-transsuccinylase from Salmonella enterica which collectively metabolize the drug Methionine, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            S-adenosylmethionine synthase 1 (MAT1A) Click to Show/Hide the Cometabolization Info
DME ID DME0189 DME Info
Uniprot ID
METK1_HUMAN
Interaction Name MAT1A-metAA interaction [1], [6]
Description The interaction, between human S-adenosylmethionine synthase 1 and Homoserine-O-transsuccinylase from Salmonella enterica which collectively metabolize the drug Methionine, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            S-adenosylmethionine synthase 2 (MAT2A) Click to Show/Hide the Cometabolization Info
DME ID DME0190 DME Info
Uniprot ID
METK2_HUMAN
Interaction Name MAT2A-metAA interaction [1], [6]
Description The interaction, between human S-adenosylmethionine synthase 2 and Homoserine-O-transsuccinylase from Salmonella enterica which collectively metabolize the drug Methionine, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
References
1 Regulation of the methionine feedback-sensitive enzyme in mutants of Salmonella typhimurium. J Bacteriol. 1972 Jan;109(1):8-11.
2 Catalytic advantages provided by selenocysteine in methionine-S-sulfoxide reductases. Biochemistry. 2006 Nov 21;45(46):13697-704.
3 The X-ray structure of the N-terminal domain of PILB from Neisseria meningitidis reveals a thioredoxin-fold. J Mol Biol. 2006 Apr 28;358(2):443-54.
4 Mutations in methylenetetrahydrofolate reductase or cystathionine beta-synthase gene, or a high-methionine diet, increase homocysteine thiolactone levels in humans and mice. FASEB J. 2007 Jun;21(8):1707-13.
5 Characterization of the amino acids involved in substrate specificity of methionine sulfoxide reductase A. J Biol Chem. 2007 Jul 13;282(28):20484-91.
6 Role of methionine adenosyltransferase 2A and S-adenosylmethionine in mitogen-induced growth of human colon cancer cells. Gastroenterology. 2007 Jul;133(1):207-18.

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