Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1465)
DME Name Cytochrome P450 102D1 (cyp102), Streptomyces avermitilis DME Info
UniProt ID
CPXB_BACMB
EC Number    EC: 1.14.14.1     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen paired donor oxidoreductase
Flavin/flavoprotein donor oxidoreductase
EC: 1.14.14.1
Lineage    Species: Streptomyces avermitilis     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Actinobacteria
Class: Actinobacteria
Order: Streptomycetales
Family: Streptomycetaceae
Genus: Streptomyces
Species: Streptomyces avermitilis
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      Drug co-metabolism
               Cometabolized drug: Coumarin Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                            Cytochrome P450 2C9 (CYP2C9) Click to Show/Hide the Cometabolization Info
DME ID DME0019 DME Info
Uniprot ID
CP2C9_HUMAN
Interaction Name CYP2C9-cyp102 interaction [1], [2], [3]
Description The interaction, between human Cytochrome P450 2C9 and Cytochrome P450 102D1 from Streptomyces avermitilis which collectively metabolize the drug Coumarin, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
               Cometabolized drug: Daidzein Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                            Sulfotransferase 2A1 (SULT2A1) Click to Show/Hide the Cometabolization Info
DME ID DME0074 DME Info
Uniprot ID
ST2A1_HUMAN
Interaction Name SULT2A1-cyp102 interaction [1], [4], [5]
Description The interaction, between human Sulfotransferase 2A1 and Cytochrome P450 102D1 from Streptomyces avermitilis which collectively metabolize the drug Daidzein, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
References
1 The metagenome of Caracolus marginella gut microbiome using culture independent approaches and shotgun sequencing. Data Brief. 2017 Nov 22;16:501-505.
2 Cloning, expression and characterization of CYP102D1, a self-sufficient P450 monooxygenase from Streptomyces avermitilis. FEBS J. 2012 May;279(9):1650-62.
3 Pharmacogenomics of CYP2C9: functional and clinical considerations. J Pers Med. 2017 Dec 28;8(1).
4 Engineering of daidzein 3'-hydroxylase P450 enzyme into catalytically self-sufficient cytochrome P450. Microb Cell Fact. 2012 Jun 14;11:81.
5 Sulfation of environmental estrogens by cytosolic human sulfotransferases. Drug Metab Pharmacokinet. 2002;17(3):221-8.

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