Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1471)
DME Name L-malate:NADP(+) oxidoreductase (maeB), Hungateiclostridium thermocellum DME Info
UniProt ID
MAO2_ECOLI
EC Number    EC: 1.1.1.40     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-OH donor oxidoreductase
NAD/NADP oxidoreductase
EC: 1.1.1.40
Lineage    Species: Hungateiclostridium thermocellum     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Hungateiclostridiaceae
Genus: Hungateiclostridium
Species: Hungateiclostridium thermocellum
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      Drug co-metabolism
               Cometabolized drug: Malate Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                            NADP-dependent malic enzyme (ME1) Click to Show/Hide the Cometabolization Info
DME ID DME0504 DME Info
Uniprot ID
MAOX_HUMAN
Interaction Name ME1-maeB interaction [1], [2], [3]
Description The interaction, between human NADP-dependent malic enzyme and L-malate:NADP(+ oxidoreductase from Hungateiclostridium thermocellum which collectively metabolize the drug Malate, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
References
1 Thermostable, ammonium-activated malic enzyme of Clostridium thermocellum. Biochim Biophys Acta. 1981 Aug 13;660(2):251-5.
2 The correlation between Clostridium-difficile infection and human gut concentrations of Bacteroidetes phylum and clostridial species. Eur J Clin Microbiol Infect Dis. 2014 Mar;33(3):377-83.
3 Structural characteristics of the nonallosteric human cytosolic malic enzyme. Biochim Biophys Acta. 2014 Oct;1844(10):1773-83.

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