Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1488)
DME Name Heparin lyase (hepB), Streptobacillus moniliformis DME Info
UniProt ID
HEPB_PEDHD
EC Number    EC: 4.2.2.7     (Click to Show/Hide the Complete EC Tree)
Lyases
Carbon-oxygen lyase
Polysaccharide-lyase
EC: 4.2.2.7
Lineage    Species: Streptobacillus moniliformis     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Fusobacteria
Class: Fusobacteriia
Order: Fusobacteriales
Family: Leptotrichiaceae
Genus: Streptobacillus
Species: Streptobacillus moniliformis
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      Drug co-metabolism
               Cometabolized drug: Heparin Click to Show/Hide the Full List of HOSPPI:        2 HOSPPI
                            Heparanase (HPSE) Click to Show/Hide the Cometabolization Info
DME ID DME0113 DME Info
Uniprot ID
HPSE_HUMAN
Interaction Name HPSE-hepB interaction [1], [2], [3]
Description The interaction, between human Heparanase and Heparin lyase from Streptobacillus moniliformis which collectively metabolize the drug Heparin, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Sulfotransferase 1A1 (SULT1A1) Click to Show/Hide the Cometabolization Info
DME ID DME0008 DME Info
Uniprot ID
ST1A1_HUMAN
Interaction Name SULT1A1-hepB interaction [1], [2], [4]
Description The interaction, between human Sulfotransferase 1A1 and Heparin lyase from Streptobacillus moniliformis which collectively metabolize the drug Heparin, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
References
1 A bacterial ABC transporter enables import of mammalian host glycosaminoglycans. Sci Rep. 2017 Apr 21;7(1):1069.
2 A case of Streptobacillus moniliformis infection with cutaneous leukocytoclastic vasculitis. Acta Med Okayama. 2016 Oct;70(5):377-381. Case Reports
3 Heparanase affects secretory granule homeostasis of murine mast cells through degrading heparin. J Allergy Clin Immunol. 2011 Dec;128(6):1310-1317.e8.
4 Characterization of a heparan sulfate 3-O-sulfotransferase-5, an enzyme synthesizing a tetrasulfated disaccharide. J Biol Chem. 2003 Jul 18;278(29):26780-7.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.